Comparative Pharmacodynamics and Pharmacokinetics of Oral Direct Thrombin and Factor Xa Inhibitors in Development

For the past five decades, there has been little progress in the development of oral anticoagulants, with the choices being limited to the vitamin K antagonists (VKAs). The situation is changing with the development of orally active small molecules that directly target thrombin or activated factor X...

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Bibliographic Details
Published in:	Clinical pharmacokinetics Vol. 48; no. 1; pp. 1 - 22
Main Authors:	Eriksson, Bengt I., Quinlan, Daniel J., Weitz, Jeffrey I.
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.01.2009 Adis International Wolters Kluwer Health, Inc Springer Nature B.V
Subjects:	Animals Antithrombin III - pharmacokinetics Antithrombin III - pharmacology Antithrombin III/pharmacokinetics/pharmacology Benzimidazoles - pharmacokinetics Benzimidazoles - pharmacology Benzimidazoles/pharmacokinetics/pharmacology Biological and medical sciences Blood coagulation factors Blood. Blood coagulation. Reticuloendothelial system Chemical properties Dabigatran Dosage and administration Drug Discovery General pharmacology Hematologic and hematopoietic diseases Humans Internal Medicine Kirurgi Medical sciences Medicine Medicine & Public Health Morpholines - pharmacokinetics Morpholines - pharmacology Morpholines/pharmacokinetics/pharmacology Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacotherapy Platelet diseases and coagulopathies Pyrazoles - pharmacokinetics Pyrazoles - pharmacology Pyrazoles/pharmacokinetics/pharmacology Pyridines - pharmacokinetics Pyridines - pharmacology Pyridines/pharmacokinetics/pharmacology Pyridones - pharmacokinetics Pyridones - pharmacology Pyridones/pharmacokinetics/pharmacology Review Article Rivaroxaban Surgery Thiophenes - pharmacokinetics Thiophenes - pharmacology Thiophenes/pharmacokinetics/pharmacology Thrombin - antagonists & inhibitors Canada United Kingdom Sweden Enoxaparin Rivaroxaban Thrombin Dabigatran Prothrombin Time Human AZD 0837 Pharmacodynamics Serine endopeptidases Enzyme Oral administration Blood-coagulation factor Xa inhibitor Anticoagulant Dabigatran etexilate Biological activity Peptidases Apixaban AR-H067637 Antithrombotic agent Development Hydrolases Pharmacokinetics Comparative study
ISSN:	0312-5963, 1179-1926
Online Access:	Get full text
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