35 Years of TFAM Research: Old Protein, New Puzzles

Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells. Thirty-five years of research on TFAM structure and function generated a considerable body of experiment...

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Veröffentlicht in:Biology (Basel, Switzerland) Jg. 12; H. 6; S. 823
Hauptverfasser: Kozhukhar, Natalya, Alexeyev, Mikhail F.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 06.06.2023
MDPI
Schlagworte:
Analysis
Bioenergetics
DNA
DNA biosynthesis
Energy
energy metabolism
Genetic transcription
Mitochondria
mitochondrial biogenesis
Mitochondrial DNA
mitochondrial DNA replication
mitochondrial DNA transcription
mitochondrial transcription factor A (TFAM)
Proteins
Review
Sedimentation & deposition
Structure-function relationships
transcription factors
mitochondrial DNA replication
mitochondrial DNA transcription
mitochondrial DNA repair
mitochondria
mitochondrial DNA
mitochondrial transcription factor A (TFAM)
mitochondrial biogenesis
ISSN:2079-7737, 2079-7737
Online-Zugang:Volltext
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Zusammenfassung:Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells. Thirty-five years of research on TFAM structure and function generated a considerable body of experimental evidence, some of which remains to be fully reconciled. Recent advancements allowed an unprecedented glimpse into the structure of TFAM complexed with promoter DNA and TFAM within the open promoter complexes. These novel insights, however, raise new questions about the function of this remarkable protein. In our review, we compile the available literature on TFAM structure and function and provide some critical analysis of the available data.
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ISSN:2079-7737
2079-7737
DOI:10.3390/biology12060823