Efficient production of astaxanthin in Yarrowia lipolytica through metabolic and enzyme engineering

Astaxanthin is a natural red carotenoid, commonly used as an additive in the pharmaceutical industry and as a nutritional supplement owing to its notable antioxidant benefits. However, a complex biosynthetic pathway poses a challenge to de novo biosynthesis of astaxanthin. Here, Yarrowia lipolytica...

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Bibliographic Details
Published in:	Synthetic and systems biotechnology Vol. 10; no. 3; pp. 737 - 750
Main Authors:	Abdullah, Chalak Najat, Liu, Mengsu, Chen, Qihang, Gao, Song, Zhang, Changtai, Liu, Shike, Zhou, Jingwen
Format:	Journal Article
Language:	English
Published:	China Elsevier B.V 01.09.2025 KeAi Publishing Communications Ltd KeAi Publishing KeAi Communications Co., Ltd
Subjects:	Algae Antioxidants Astaxanthin Bacteria Batch culture Biosynthesis Carotene Carotenoids Catalytic activity CRISPR Dietary supplements E coli Enzyme engineering Enzymes Fermentation Genes Genomes Glucose Metabolic engineering Modular enzyme assembly Organelles Original Pharmaceutical industry Plasmids Productivity Subcellular organelles Yarrowia lipolytica Yeast β-Carotene China Shanghai China Modular enzyme assembly Subcellular organelles Enzyme engineering Astaxanthin Yarrowia lipolytica
ISSN:	2405-805X, 2405-805X
Online Access:	Get full text
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