Activated Platelets Induce Endothelial Cell Inflammatory Response in Psoriasis via COX-1

Patients with psoriasis have impaired vascular health and increased cardiovascular disease (CVD). Platelets are key players in the pathogenesis of vascular dysfunction in cardiovascular disease and represent therapeutic targets in cardiovascular prevention. The object of this study was to define the...

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Vydáno v:Arteriosclerosis, thrombosis, and vascular biology Ročník 40; číslo 5; s. 1340
Hlavní autoři: Garshick, Michael S, Tawil, Michael, Barrett, Tessa J, Salud-Gnilo, Charissa M, Eppler, Michael, Lee, Angela, Scher, Jose U, Neimann, Andrea L, Jelic, Sanja, Mehta, Nehal N, Fisher, Edward A, Krueger, James G, Berger, Jeffrey S
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.05.2020
Témata:
Adult
Aspirin - administration & dosage
Blood Platelets - drug effects
Blood Platelets - enzymology
Cells, Cultured
Cyclooxygenase 1 - blood
Cyclooxygenase 1 - genetics
Cyclooxygenase Inhibitors - administration & dosage
Endothelial Cells - drug effects
Endothelial Cells - enzymology
Female
Humans
Male
Middle Aged
Platelet Activation
Platelet Adhesiveness
Psoriasis - blood
Psoriasis - diagnosis
Psoriasis - drug therapy
Psoriasis - enzymology
Severity of Illness Index
Signal Transduction
Thromboxane B2 - blood
Treatment Outcome
endothelium
aspirin
inflammation
psoriasis
platelet aggregation
ISSN:1524-4636, 1524-4636
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Shrnutí:Patients with psoriasis have impaired vascular health and increased cardiovascular disease (CVD). Platelets are key players in the pathogenesis of vascular dysfunction in cardiovascular disease and represent therapeutic targets in cardiovascular prevention. The object of this study was to define the platelet phenotype and effector cell properties on vascular health in psoriasis and evaluate whether aspirin modulates the platelet-induced phenotype. Approach and Results: Platelets from psoriasis patients (n=45) exhibited increased platelet activation (relative to age- and gender-matched controls, n=18), which correlated with psoriasis skin severity. Isolated platelets from psoriasis patients demonstrated a 2- to 3-fold ( <0.01) increased adhesion to human aortic endothelial cells and induced proinflammatory transcriptional changes, including upregulation of (interleukin 8), , and Cox (cyclooxygenase)-2 Platelet RNA sequencing revealed an interferon signature and elevated expression of , which correlated with psoriasis disease severity ( =0.83, =0.01). In a randomized trial of patients with psoriasis, 2 weeks of 81 mg low-dose aspirin, a COX-1 inhibitor, reduced serum thromboxane (Tx) B and reduced brachial vein endothelial proinflammatory transcript expression >70% compared with the no-treatment group ( <0.01). Improvement in brachial vein endothelial cell inflammation significantly correlated with change in serum TxB ( =0.48, =0.02). In patients with psoriasis, platelets are activated and induce endothelial cell inflammation. Low-dose aspirin improved endothelial cell health in psoriasis via platelet COX-1 inhibition. These data demonstrate a previously unappreciated role of platelets in psoriasis and endothelial cell inflammation and suggests that aspirin may be effective in improving vascular health in patients with psoriasis. Registration: URL: http://www.clinicaltrials.gov. Unique identifier: NCT03228017.
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ISSN:1524-4636
1524-4636
DOI:10.1161/ATVBAHA.119.314008