Cytokines as biomarkers of Crimean-Congo hemorrhagic fever

Crimean‐Congo hemorrhagic fever (CCHF) is a potentially severe disease caused by CCHF virus. As in other viral hemorrhagic fevers, it is considered that the course and outcome of the disease depend on the viral load and the balance among the immune response mediators, and that a fatal outcome is the...

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Published in:Journal of medical virology Vol. 88; no. 1; pp. 21 - 27
Main Authors: Papa, Anna, Tsergouli, Katerina, Çağlayık, Dilek Yağcı, Bino, Silvia, Como, Najada, Uyar, Yavuz, Korukluoglu, Gulay
Format: Journal Article
Language:English
Published: United States Blackwell Publishing Ltd 01.01.2016
Wiley Subscription Services, Inc
Subjects:
Adolescent
Adult
Aged
Biomarkers
Biomarkers - blood
chemokines
Child
Child, Preschool
Crimean-Congo hemorrhagic fever
Cytokines
Cytokines - blood
Ebola virus
Female
Fever
Hemorrhagic Fever, Crimean - pathology
Hemorrhagic Fever, Crimean - virology
Humans
Male
Middle Aged
Viral Load
Virology
Young Adult
cytokines
chemokines
biomarkers
Crimean-Congo hemorrhagic fever
ISSN:0146-6615, 1096-9071
Online Access:Get full text
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Summary:Crimean‐Congo hemorrhagic fever (CCHF) is a potentially severe disease caused by CCHF virus. As in other viral hemorrhagic fevers, it is considered that the course and outcome of the disease depend on the viral load and the balance among the immune response mediators, and that a fatal outcome is the result of a “cytokine storm.” The level of 27 cytokines was measured in serum samples taken from 29 patients during the acute phase of the disease. Two cases were fatal. Among survivors, significant differences between severe and non‐severe cases were observed in the levels of IP‐10, and MCP‐1, while the levels of IL‐1b, IL‐5, IL‐6, IL‐8, IL‐9, IL‐10, IL‐15, IP‐10, MCP‐1, TNF‐α, and RANTES differed significantly between fatal and non‐fatal cases (P < 0.05). RANTES was negatively correlated with the outcome of the disease. A striking similarity with the cytokine patterns seen in Ebola virus disease was observed. A weak Th1 immune response was seen. The viral load was positively correlated with IL‐10, IP‐10, and MCP‐1 levels, and negatively correlated with the ratio IL‐12/IL‐10. Especially IP‐10 and MCP‐1 were significantly associated with the viral load, the severity and outcome of the disease, and they could act as biomarkers and, probably, as potential targets for treatment strategies design. J. Med. Virol. 88:21–27, 2016. © 2015 Wiley Periodicals, Inc.
Bibliography:ark:/67375/WNG-RXNM4Z7H-G
ArticleID:JMV24312
istex:8B76D3DED52B701017533EF3E7CBD7B1F99AC261
European Commission - No. 260427
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
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ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.24312