Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice

We have used large-scale insertional mutagenesis to identify functional landmarks relevant to cancer in the recently completed mouse genome sequence. We infected Cdkn2a −/− mice with Moloney murine leukemia virus (MoMuLV) to screen for loci that can participate in tumorigenesis in collaboration with...

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Bibliographic Details
Published in:	Nature genetics Vol. 32; no. 1; pp. 160 - 165
Main Authors:	Lund, Anders H., Turner, Geoffrey, Trubetskoy, Alla, Verhoeven, Els, Wientjens, Ellen, Hulsman, Danielle, Russell, Robert, DePinho, Ronald A., Lenz, Jack, van Lohuizen, Maarten
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.09.2002 Nature Publishing Group
Subjects:	Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell Transformation, Neoplastic Cells, Cultured Chromosome Mapping Classical genetics, quantitative genetics, hybrids Collaboration Complications and side effects Cyclin-Dependent Kinase Inhibitor p16 - deficiency Cyclin-Dependent Kinase Inhibitor p16 - genetics Diagnosis Fundamental and applied biological sciences. Psychology Gene expression Gene Function Gene loci Gene mutations Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution Genome Genomes Genomics Health aspects Human Genetics Humans Infections Kinases letter Leukemia Lymphoma Lymphoma - genetics Mice Molecular Sequence Data Moloney murine leukemia virus Moloney murine leukemia virus - genetics Mutagenesis Mutagenesis, Insertional Neoplasms - genetics Proviruses - genetics Retrovirus Risk factors Sarcoma Spleen Tumorigenesis Tumors Vertebrata Netherlands United States > US Vertebrata Mammalia Gene Mouse Rodentia Tagging Malignant tumor Genome
ISSN:	1061-4036, 1546-1718
Online Access:	Get full text
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