Pathophysiological Role of Neuroinflammation in Neurodegenerative Diseases and Psychiatric Disorders
Brain diseases and disorders such as Alzheimer disease, Parkinson disease, depression, schizophrenia, autism, and addiction lead to reduced quality of daily life through abnormal thoughts, perceptions, emotional states, and behavior. While the underlying mechanisms remain poorly understood, human an...
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| Published in: | International neurourology journal Vol. 20; no. Suppl 1; pp. S2 - 7 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Korea (South)
Korean Continence Society
01.05.2016
대한배뇨장애요실금학회 |
| Subjects: | |
| ISSN: | 2093-6931, 2093-4777, 2093-6931 |
| Online Access: | Get full text |
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| Summary: | Brain diseases and disorders such as Alzheimer disease, Parkinson disease, depression, schizophrenia, autism, and addiction lead to reduced quality of daily life through abnormal thoughts, perceptions, emotional states, and behavior. While the underlying mechanisms remain poorly understood, human and animal studies have supported a role of neuroinflammation in the etiology of these diseases. In the central nervous system, an increased inflammatory response is capable of activating microglial cells, leading to the release of pro-inflammatory cytokines including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α. In turn, the pro-inflammatory cytokines aggravate and propagate neuroinflammation, degenerating healthy neurons and impairing brain functions. Therefore, activated microglia may play a key role in neuroinflammatory processes contributing to the pathogenesis of psychiatric disorders and neurodegeneration. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 G704-001728.2016.20..004 |
| ISSN: | 2093-6931 2093-4777 2093-6931 |
| DOI: | 10.5213/inj.1632604.302 |