Pathophysiological Role of Neuroinflammation in Neurodegenerative Diseases and Psychiatric Disorders

Brain diseases and disorders such as Alzheimer disease, Parkinson disease, depression, schizophrenia, autism, and addiction lead to reduced quality of daily life through abnormal thoughts, perceptions, emotional states, and behavior. While the underlying mechanisms remain poorly understood, human an...

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Veröffentlicht in:International neurourology journal Jg. 20; H. Suppl 1; S. S2 - 7
Hauptverfasser: Hong, Heeok, Kim, Byung Sun, Im, Heh-In
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Korea (South) Korean Continence Society 01.05.2016
대한배뇨장애요실금학회
Schlagworte:
Brain Diseases
Cytokines
Inflammation
Microglia
Review
비뇨기과학
Brain Diseases
Inflammation
Cytokines
Microglia
ISSN:2093-6931, 2093-4777, 2093-6931
Online-Zugang:Volltext
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Zusammenfassung:Brain diseases and disorders such as Alzheimer disease, Parkinson disease, depression, schizophrenia, autism, and addiction lead to reduced quality of daily life through abnormal thoughts, perceptions, emotional states, and behavior. While the underlying mechanisms remain poorly understood, human and animal studies have supported a role of neuroinflammation in the etiology of these diseases. In the central nervous system, an increased inflammatory response is capable of activating microglial cells, leading to the release of pro-inflammatory cytokines including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α. In turn, the pro-inflammatory cytokines aggravate and propagate neuroinflammation, degenerating healthy neurons and impairing brain functions. Therefore, activated microglia may play a key role in neuroinflammatory processes contributing to the pathogenesis of psychiatric disorders and neurodegeneration.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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G704-001728.2016.20..004
ISSN:2093-6931
2093-4777
2093-6931
DOI:10.5213/inj.1632604.302