SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism

Macrophages play pivotal roles in both the induction and resolution phases of inflammatory processes. Macrophages have been shown to synthesize anti-inflammatory fatty acids in an LXR-dependent manner, but whether the production of these species contributes to the resolution phase of inflammatory re...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Cell metabolism Ročník 25; číslo 2; s. 412
Hlavní autoři:	Oishi, Yumiko, Spann, Nathanael J, Link, Verena M, Muse, Evan D, Strid, Tobias, Edillor, Chantle, Kolar, Matthew J, Matsuzaka, Takashi, Hayakawa, Sumio, Tao, Jenhan, Kaikkonen, Minna U, Carlin, Aaron F, Lam, Michael T, Manabe, Ichiro, Shimano, Hitoshi, Saghatelian, Alan, Glass, Christopher K
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 07.02.2017
Témata:	Animals Base Sequence Biosynthetic Pathways - drug effects Biosynthetic Pathways - genetics Enhancer Elements, Genetic - genetics Fatty Acids - metabolism Inflammation - genetics Inflammation - pathology Lipid Metabolism - drug effects Lipopolysaccharides - pharmacology Liver X Receptors - metabolism Macrophages - drug effects Macrophages - metabolism Male Mice, Inbred C57BL Phenotype Signal Transduction - drug effects Sterol Regulatory Element Binding Protein 1 - metabolism Time Factors Toll-Like Receptor 4 - metabolism innate immunity unsaturated fatty acids inflammation fatty acid metabolism transcriptional regulation EPA lipid metabolism SREBP1 DHA resolution
ISSN:	1932-7420, 1932-7420
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Macrophages play pivotal roles in both the induction and resolution phases of inflammatory processes. Macrophages have been shown to synthesize anti-inflammatory fatty acids in an LXR-dependent manner, but whether the production of these species contributes to the resolution phase of inflammatory responses has not been established. Here, we identify a biphasic program of gene expression that drives production of anti-inflammatory fatty acids 12-24 hr following TLR4 activation and contributes to downregulation of mRNAs encoding pro-inflammatory mediators. Unexpectedly, rather than requiring LXRs, this late program of anti-inflammatory fatty acid biosynthesis is dependent on SREBP1 and results in the uncoupling of NFκB binding from gene activation. In contrast to previously identified roles of SREBP1 in promoting production of IL1β during the induction phase of inflammation, these studies provide evidence that SREBP1 also contributes to the resolution phase of TLR4-induced gene activation by reprogramming macrophage lipid metabolism.
AbstractList	Macrophages play pivotal roles in both the induction and resolution phases of inflammatory processes. Macrophages have been shown to synthesize anti-inflammatory fatty acids in an LXR-dependent manner, but whether the production of these species contributes to the resolution phase of inflammatory responses has not been established. Here, we identify a biphasic program of gene expression that drives production of anti-inflammatory fatty acids 12-24 hr following TLR4 activation and contributes to downregulation of mRNAs encoding pro-inflammatory mediators. Unexpectedly, rather than requiring LXRs, this late program of anti-inflammatory fatty acid biosynthesis is dependent on SREBP1 and results in the uncoupling of NFκB binding from gene activation. In contrast to previously identified roles of SREBP1 in promoting production of IL1β during the induction phase of inflammation, these studies provide evidence that SREBP1 also contributes to the resolution phase of TLR4-induced gene activation by reprogramming macrophage lipid metabolism.Macrophages play pivotal roles in both the induction and resolution phases of inflammatory processes. Macrophages have been shown to synthesize anti-inflammatory fatty acids in an LXR-dependent manner, but whether the production of these species contributes to the resolution phase of inflammatory responses has not been established. Here, we identify a biphasic program of gene expression that drives production of anti-inflammatory fatty acids 12-24 hr following TLR4 activation and contributes to downregulation of mRNAs encoding pro-inflammatory mediators. Unexpectedly, rather than requiring LXRs, this late program of anti-inflammatory fatty acid biosynthesis is dependent on SREBP1 and results in the uncoupling of NFκB binding from gene activation. In contrast to previously identified roles of SREBP1 in promoting production of IL1β during the induction phase of inflammation, these studies provide evidence that SREBP1 also contributes to the resolution phase of TLR4-induced gene activation by reprogramming macrophage lipid metabolism. Macrophages play pivotal roles in both the induction and resolution phases of inflammatory processes. Macrophages have been shown to synthesize anti-inflammatory fatty acids in an LXR-dependent manner, but whether the production of these species contributes to the resolution phase of inflammatory responses has not been established. Here, we identify a biphasic program of gene expression that drives production of anti-inflammatory fatty acids 12-24 hr following TLR4 activation and contributes to downregulation of mRNAs encoding pro-inflammatory mediators. Unexpectedly, rather than requiring LXRs, this late program of anti-inflammatory fatty acid biosynthesis is dependent on SREBP1 and results in the uncoupling of NFκB binding from gene activation. In contrast to previously identified roles of SREBP1 in promoting production of IL1β during the induction phase of inflammation, these studies provide evidence that SREBP1 also contributes to the resolution phase of TLR4-induced gene activation by reprogramming macrophage lipid metabolism.
Author	Kolar, Matthew J Spann, Nathanael J Hayakawa, Sumio Link, Verena M Matsuzaka, Takashi Saghatelian, Alan Oishi, Yumiko Muse, Evan D Glass, Christopher K Kaikkonen, Minna U Shimano, Hitoshi Manabe, Ichiro Tao, Jenhan Lam, Michael T Edillor, Chantle Strid, Tobias Carlin, Aaron F
Author_xml	– sequence: 1 givenname: Yumiko surname: Oishi fullname: Oishi, Yumiko email: yuooishi-circ@umin.ac.jp organization: Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan. Electronic address: yuooishi-circ@umin.ac.jp – sequence: 2 givenname: Nathanael J surname: Spann fullname: Spann, Nathanael J organization: Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA – sequence: 3 givenname: Verena M surname: Link fullname: Link, Verena M organization: Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department II, Faculty of Biology, Ludwig-Maximilians Universität München, Planegg-Martinsried 82152, Germany – sequence: 4 givenname: Evan D surname: Muse fullname: Muse, Evan D organization: Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Scripps Translational Science Institute, La Jolla, CA 92037, USA – sequence: 5 givenname: Tobias surname: Strid fullname: Strid, Tobias organization: Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA – sequence: 6 givenname: Chantle surname: Edillor fullname: Edillor, Chantle organization: Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA – sequence: 7 givenname: Matthew J surname: Kolar fullname: Kolar, Matthew J organization: Salk Institute for Biological Studies, La Jolla, CA 92037, USA – sequence: 8 givenname: Takashi surname: Matsuzaka fullname: Matsuzaka, Takashi organization: Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, Graduate School of Comprehensive Human Sciences, International Institute for Integrative Sleep Medicine (WPI-IIIS), and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki Prefecture 305-8571, Japan – sequence: 9 givenname: Sumio surname: Hayakawa fullname: Hayakawa, Sumio organization: Department of Cellular and Molecular Medicine, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan – sequence: 10 givenname: Jenhan surname: Tao fullname: Tao, Jenhan organization: Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA – sequence: 11 givenname: Minna U surname: Kaikkonen fullname: Kaikkonen, Minna U organization: Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland – sequence: 12 givenname: Aaron F surname: Carlin fullname: Carlin, Aaron F organization: Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA – sequence: 13 givenname: Michael T surname: Lam fullname: Lam, Michael T organization: Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA – sequence: 14 givenname: Ichiro surname: Manabe fullname: Manabe, Ichiro organization: Department of Aging Research, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan – sequence: 15 givenname: Hitoshi surname: Shimano fullname: Shimano, Hitoshi organization: Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, Graduate School of Comprehensive Human Sciences, International Institute for Integrative Sleep Medicine (WPI-IIIS), and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki Prefecture 305-8571, Japan – sequence: 16 givenname: Alan surname: Saghatelian fullname: Saghatelian, Alan organization: Salk Institute for Biological Studies, La Jolla, CA 92037, USA – sequence: 17 givenname: Christopher K surname: Glass fullname: Glass, Christopher K email: ckg@ucsd.edu organization: Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: ckg@ucsd.edu
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28041958$$D View this record in MEDLINE/PubMed
BookMark	eNpNkEtPwzAQhC1URB_wBzggH7kk-BEn9rFULSAFUbXlHNmJU7lK7BI7h_x7gigSl93R6pvVaOZgYp3VANxjFGOE06dTXLY6xGTUMcYxQuIKzLCgJMoSgib_9BTMvT8hRFMq6A2YEo4SLBifgdN-t37eYrhyNnRG9UF7GBzcae-aPhhnoavhtnORsXUj21YG1w3wkO8SuDdHKxtjj1ANo-HcuWM3Ej-HjQxhgMvSVPBdB6lcY3x7C65r2Xh9d9kL8LlZH1avUf7x8rZa5lHJmAiRwIxmKaqUlDgpma5QpsqM04wrlXFUI4ErRCjVvE5qmtU4TSRhiqSlVuOsyAI8_v4dE3312oeiNb7UTSOtdr0vMGcJH6sQbEQfLmivWl0V5860shuKv37IN-hdamY
CitedBy_id	crossref_primary_10_1016_j_ijbiomac_2025_144076 crossref_primary_10_3389_fnut_2021_765147 crossref_primary_10_1016_j_intimp_2023_110502 crossref_primary_10_1097_MOL_0000000000000464 crossref_primary_10_1186_s12943_025_02416_5 crossref_primary_10_1016_j_mam_2020_100918 crossref_primary_10_3389_fimmu_2023_1157291 crossref_primary_10_1016_j_tibs_2018_01_005 crossref_primary_10_3390_nu11112618 crossref_primary_10_1186_s12944_019_1136_y crossref_primary_10_3390_ijms24054342 crossref_primary_10_1172_JCI124219 crossref_primary_10_1093_jleuko_qiac011 crossref_primary_10_3389_fimmu_2022_1050188 crossref_primary_10_1007_s00281_018_0707_8 crossref_primary_10_1016_j_bbadis_2024_167580 crossref_primary_10_3390_ijerph21020177 crossref_primary_10_3389_fcell_2021_693342 crossref_primary_10_1016_j_biopha_2023_114254 crossref_primary_10_1210_endocr_bqac040 crossref_primary_10_1161_JAHA_120_019473 crossref_primary_10_1073_pnas_2005924117 crossref_primary_10_1016_j_phymed_2025_157167 crossref_primary_10_1073_pnas_2020322118 crossref_primary_10_1172_JCI148552 crossref_primary_10_1016_j_tcb_2020_09_006 crossref_primary_10_1016_j_tem_2024_04_017 crossref_primary_10_3390_nu12092588 crossref_primary_10_3390_molecules28020517 crossref_primary_10_3390_cancers14235805 crossref_primary_10_1038_s41467_024_48637_y crossref_primary_10_1096_fba_2023_00084 crossref_primary_10_1210_en_2018_00093 crossref_primary_10_3389_fimmu_2021_760322 crossref_primary_10_1093_intimm_dxy054 crossref_primary_10_34067_KID_0000772019 crossref_primary_10_1016_j_isci_2023_107866 crossref_primary_10_1016_j_yexcr_2023_113869 crossref_primary_10_1152_ajpendo_00009_2025 crossref_primary_10_1097_MOL_0000000000000448 crossref_primary_10_1161_CIRCRESAHA_124_325310 crossref_primary_10_1038_s42255_023_00786_y crossref_primary_10_1186_s40104_022_00774_4 crossref_primary_10_1097_ICO_0000000000003381 crossref_primary_10_1016_j_ymthe_2018_01_008 crossref_primary_10_1016_j_cmet_2019_10_014 crossref_primary_10_1016_j_intimp_2022_108961 crossref_primary_10_1093_nar_gkaf880 crossref_primary_10_1016_j_cmet_2020_05_003 crossref_primary_10_1016_j_jlr_2022_100325 crossref_primary_10_1038_s41418_022_00992_3 crossref_primary_10_1038_s41467_022_34532_x crossref_primary_10_3390_cancers17101664 crossref_primary_10_1016_j_intimp_2023_110891 crossref_primary_10_1093_intimm_dxaa020 crossref_primary_10_3390_genes13112057 crossref_primary_10_1128_MCB_00364_19 crossref_primary_10_1017_S0022029918000547 crossref_primary_10_1073_pnas_2406492121 crossref_primary_10_3389_fonc_2021_751086 crossref_primary_10_1016_j_imbio_2021_152150 crossref_primary_10_1016_j_jccase_2022_08_001 crossref_primary_10_1002_advs_202307201 crossref_primary_10_1038_s41590_023_01631_w crossref_primary_10_1093_jleuko_qiae102 crossref_primary_10_3389_fimmu_2023_1118449 crossref_primary_10_1038_s41392_022_00964_6 crossref_primary_10_1038_s41419_023_06066_7 crossref_primary_10_1073_pnas_1919403117 crossref_primary_10_1074_jbc_RA119_011849 crossref_primary_10_1007_s11883_018_0715_0 crossref_primary_10_1016_j_cytogfr_2025_06_007 crossref_primary_10_3390_ijms24086885 crossref_primary_10_3389_fimmu_2025_1547949 crossref_primary_10_3390_nu12092892 crossref_primary_10_3389_fphys_2020_588082 crossref_primary_10_3390_ijms26136345 crossref_primary_10_1080_14728222_2022_2117610 crossref_primary_10_1186_s12883_019_1369_4 crossref_primary_10_1210_endocr_bqaa189 crossref_primary_10_1016_j_intimp_2024_112319 crossref_primary_10_3389_fimmu_2024_1495853 crossref_primary_10_1016_j_atherosclerosis_2019_10_002 crossref_primary_10_1016_j_cell_2018_04_018 crossref_primary_10_1177_09731296251342376 crossref_primary_10_1002_med_21515 crossref_primary_10_3390_ijms20153787 crossref_primary_10_1530_JME_17_0289 crossref_primary_10_3389_fpsyt_2020_00256 crossref_primary_10_1016_j_mad_2025_112043 crossref_primary_10_1038_s41420_021_00744_1 crossref_primary_10_1101_gad_313973_118 crossref_primary_10_3390_metabo10080332 crossref_primary_10_1016_j_psj_2025_105577 crossref_primary_10_1096_fj_202402797RR crossref_primary_10_1038_nrendo_2017_91 crossref_primary_10_1016_j_nbd_2021_105290 crossref_primary_10_1038_s42255_020_00270_x crossref_primary_10_1186_s13046_019_1492_5 crossref_primary_10_1007_s00125_018_4708_x crossref_primary_10_1002_jev2_12394 crossref_primary_10_1002_1873_3468_12702 crossref_primary_10_1146_annurev_immunol_042718_041739 crossref_primary_10_1016_j_lfs_2021_119040 crossref_primary_10_3389_fmed_2023_1124008 crossref_primary_10_3390_genes12050700 crossref_primary_10_1007_s13679_025_00626_y crossref_primary_10_3389_fimmu_2022_923727 crossref_primary_10_3390_ijms26010111 crossref_primary_10_3390_ijms21165731 crossref_primary_10_1016_j_jid_2019_10_014 crossref_primary_10_1161_CIRCGEN_120_003196 crossref_primary_10_1038_s41590_019_0582_z crossref_primary_10_1016_j_immuni_2020_04_001 crossref_primary_10_1093_toxres_tfad028 crossref_primary_10_1111_cod_14711 crossref_primary_10_1016_j_scitotenv_2024_174979 crossref_primary_10_1073_pnas_1911992116 crossref_primary_10_1016_j_semcdb_2017_07_011 crossref_primary_10_1038_s41467_025_56565_8 crossref_primary_10_1155_2020_3920196 crossref_primary_10_1002_iid3_70243 crossref_primary_10_1016_j_lfs_2024_123188 crossref_primary_10_1016_j_taap_2018_05_006 crossref_primary_10_3390_microorganisms7080216 crossref_primary_10_1007_s11357_025_01539_3 crossref_primary_10_1111_sji_12713 crossref_primary_10_1172_JCI124619 crossref_primary_10_15212_AMM_2025_0001 crossref_primary_10_1038_s41467_022_31388_z crossref_primary_10_3389_fphar_2024_1441105 crossref_primary_10_1016_j_bbalip_2019_04_015 crossref_primary_10_1128_IAI_00788_20 crossref_primary_10_3389_fcell_2021_617073 crossref_primary_10_1007_s10555_023_10156_5 crossref_primary_10_3389_fimmu_2020_00353 crossref_primary_10_3389_fmolb_2022_918346 crossref_primary_10_3389_fonc_2020_618515 crossref_primary_10_1194_jlr_M076489 crossref_primary_10_2217_imt_2018_0006 crossref_primary_10_1016_j_molmed_2025_07_006 crossref_primary_10_3389_fmicb_2023_1115556 crossref_primary_10_1038_s41467_017_01232_w crossref_primary_10_1161_CIRCULATIONAHA_122_059062 crossref_primary_10_2147_JIR_S327858 crossref_primary_10_1084_jem_20241232 crossref_primary_10_1038_s41586_021_03960_y crossref_primary_10_3390_antiox13121540 crossref_primary_10_1186_s13059_021_02460_6 crossref_primary_10_3389_fimmu_2022_926220 crossref_primary_10_1007_s00251_024_01334_y crossref_primary_10_3389_fimmu_2025_1617570 crossref_primary_10_1042_BCJ20210071 crossref_primary_10_1073_pnas_1813458115 crossref_primary_10_1080_2162402X_2018_1554967 crossref_primary_10_1002_jmv_26743 crossref_primary_10_1016_j_theriogenology_2020_01_012 crossref_primary_10_1038_s44355_024_00015_7 crossref_primary_10_1186_s40364_024_00621_w crossref_primary_10_3390_ijms25052670 crossref_primary_10_1016_j_immuni_2019_06_005 crossref_primary_10_1111_febs_16076 crossref_primary_10_1002_1873_3468_12850 crossref_primary_10_1038_s41590_020_0695_4 crossref_primary_10_1002_eji_202048944 crossref_primary_10_1016_j_bbalip_2021_159066 crossref_primary_10_3389_fonc_2021_715593 crossref_primary_10_1007_s00018_023_04745_4 crossref_primary_10_15252_embj_2019101732 crossref_primary_10_1111_bph_15286 crossref_primary_10_3390_ijms25126312 crossref_primary_10_1182_blood_2021012788 crossref_primary_10_1016_j_aquaculture_2022_739088 crossref_primary_10_3389_fphar_2025_1572592 crossref_primary_10_3389_fcvm_2020_00064 crossref_primary_10_3389_fonc_2022_979565 crossref_primary_10_3389_fneur_2024_1411555 crossref_primary_10_1016_j_lfs_2023_121512 crossref_primary_10_1093_jn_nxab425 crossref_primary_10_1016_j_intimp_2024_113019 crossref_primary_10_1186_s12974_022_02664_y crossref_primary_10_1038_s41598_022_16017_5 crossref_primary_10_1038_s41598_019_39876_x crossref_primary_10_1080_09712119_2025_2462577 crossref_primary_10_1016_j_fsi_2022_05_003 crossref_primary_10_1007_s11892_019_1143_4 crossref_primary_10_1038_s41419_023_05741_z crossref_primary_10_1002_2211_5463_13364 crossref_primary_10_1038_s42255_021_00440_5 crossref_primary_10_1172_JCI175445 crossref_primary_10_1016_j_ajpath_2021_10_002 crossref_primary_10_3389_fimmu_2020_609618 crossref_primary_10_1002_JLB_3HI0918_373R crossref_primary_10_1038_s41598_017_07100_3 crossref_primary_10_1039_D0FO00442A crossref_primary_10_1039_D0FO01107J crossref_primary_10_1096_fj_201801123R crossref_primary_10_3390_ijms21155505 crossref_primary_10_3389_fimmu_2023_1251784 crossref_primary_10_3389_fimmu_2019_03133 crossref_primary_10_1159_000516780 crossref_primary_10_1002_mco2_658 crossref_primary_10_1155_2018_1943497 crossref_primary_10_3390_biology6020028 crossref_primary_10_1016_j_fbio_2023_102549 crossref_primary_10_1016_j_fct_2022_113421 crossref_primary_10_1016_j_chom_2025_08_011 crossref_primary_10_1016_j_jep_2024_117838 crossref_primary_10_1016_j_freeradbiomed_2025_08_035 crossref_primary_10_1016_j_ymthe_2022_02_021 crossref_primary_10_1136_ard_2023_224055 crossref_primary_10_3389_fimmu_2021_631714 crossref_primary_10_1016_j_intimp_2022_109171 crossref_primary_10_1124_pharmrev_121_000436 crossref_primary_10_1093_burnst_tkad047 crossref_primary_10_3389_fimmu_2021_774177 crossref_primary_10_1111_bph_15642 crossref_primary_10_7554_eLife_71946 crossref_primary_10_7554_eLife_48609 crossref_primary_10_1111_imr_13214 crossref_primary_10_3389_fimmu_2023_1009973 crossref_primary_10_3389_fcell_2020_00661 crossref_primary_10_1507_endocrj_EJ25_0180 crossref_primary_10_3389_fendo_2020_00062 crossref_primary_10_3390_ijms19113463 crossref_primary_10_3390_ijms24054309 crossref_primary_10_1016_j_cellimm_2018_01_020 crossref_primary_10_1016_j_mmm_2020_06_017 crossref_primary_10_3390_molecules26165096 crossref_primary_10_1016_j_wneu_2025_123723 crossref_primary_10_1038_s41598_017_12434_z crossref_primary_10_1097_HEP_0000000000001371 crossref_primary_10_1002_lci2_68 crossref_primary_10_1016_j_tem_2022_02_005 crossref_primary_10_1016_j_plipres_2022_101207 crossref_primary_10_1186_s12967_023_04569_7
ContentType	Journal Article
Copyright	Copyright © 2017 Elsevier Inc. All rights reserved.
Copyright_xml	– notice: Copyright © 2017 Elsevier Inc. All rights reserved.
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1016/j.cmet.2016.11.009
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Biology
EISSN	1932-7420
ExternalDocumentID	28041958
Genre	Journal Article
GrantInformation_xml	– fundername: NIGMS NIH HHS grantid: T32 GM007198 – fundername: NCI NIH HHS grantid: P30 CA014195 – fundername: NIDDK NIH HHS grantid: P01 DK074868 – fundername: NCI NIH HHS grantid: R01 CA173903 – fundername: NHLBI NIH HHS grantid: R21 HL088083 – fundername: NIDDK NIH HHS grantid: R01 DK091183 – fundername: NIDDK NIH HHS grantid: P30 DK063491
GroupedDBID	--- --K 0R~ 1~5 29B 2WC 4.4 457 4G. 53G 5GY 62- 6J9 7-5 AACTN AAEDT AAEDW AAKRW AAKUH AALRI AAMRU AAVLU AAXUO ABJNI ABMAC ACGFO ACGFS ADBBV ADEZE ADVLN AEFWE AENEX AEXQZ AFTJW AGKMS AITUG AKAPO AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ ASPBG AVWKF AZFZN BAWUL CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P FCP FDB FEDTE FIRID HVGLF IHE IXB J1W JIG M3Z M41 NPM O-L O9- OK1 P2P RIG ROL RPZ SES SSZ TR2 UNMZH 7X8 AAYWO ABDGV ACVFH ADCNI AEUPX AFPUW AIGII AKBMS AKYEP APXCP EFKBS
ID	FETCH-LOGICAL-c559t-9153760dbaa14c5ed07bc78378bb780f091d0233e8f4f37f164a25b26cebb26d2
IEDL.DBID	7X8
ISICitedReferencesCount	273
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000396354400021&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-7420
IngestDate	Mon Sep 29 05:38:51 EDT 2025 Thu Apr 03 07:06:17 EDT 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	2
Keywords	innate immunity unsaturated fatty acids inflammation fatty acid metabolism transcriptional regulation EPA lipid metabolism SREBP1 DHA resolution
Language	English
License	Copyright © 2017 Elsevier Inc. All rights reserved.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c559t-9153760dbaa14c5ed07bc78378bb780f091d0233e8f4f37f164a25b26cebb26d2
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	http://www.cell.com/article/S1550413116305885/pdf
PMID	28041958
PQID	1854803695
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_1854803695 pubmed_primary_28041958
PublicationCentury	2000
PublicationDate	2017-02-07
PublicationDateYYYYMMDD	2017-02-07
PublicationDate_xml	– month: 02 year: 2017 text: 2017-02-07 day: 07
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Cell metabolism
PublicationTitleAlternate	Cell Metab
PublicationYear	2017
References	11994399 - J Clin Invest. 2002 May;109(9):1125-31 23021221 - Cell. 2012 Sep 28;151(1):138-52 21531336 - Cell Metab. 2011 May 4;13(5):540-9 23959186 - Nat Immunol. 2013 Sep;14(9):893-900 20498354 - J Immunol. 2010 Jul 1;185(1):605-14 26681459 - Nat Immunol. 2016 Jan;17(1):26-33 21041726 - J Immunol. 2010 Dec 1;185(11):6599-607 18829989 - Diabetes. 2008 Dec;57(12):3239-46 19859064 - Nat Rev Immunol. 2009 Oct;9(10):692-703 24833295 - Nat Rev Drug Discov. 2014 Jun;13(6):433-44 21106759 - Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21931-6 9329978 - J Clin Invest. 1997 Oct 15;100(8):2115-24 19299558 - Genes Dev. 2009 Mar 15;23 (6):681-93 23535595 - Nature. 2013 Apr 11;496(7444):238-42 11090131 - Genes Dev. 2000 Nov 15;14 (22):2831-8 25805830 - FASEB J. 2015 Jul;29(7):2959-69 23332752 - Cell. 2013 Jan 17;152(1-2):157-71 20513432 - Mol Cell. 2010 May 28;38(4):576-89 26173179 - Elife. 2015 Jul 14;4:e08009 19336660 - Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1300-10 23746697 - Trends Mol Med. 2013 Aug;19(8):487-500 16413480 - Cell. 2006 Jan 13;124(1):35-46 12524534 - Nat Med. 2003 Feb;9(2):213-9 25104388 - Science. 2014 Aug 8;345(6197):679-84 22395709 - Nat Med. 2012 Mar 06;18(3):363-74 23307734 - Science. 2013 Jan 11;339(6116):166-72 10968783 - Science. 2000 Sep 1;289(5484):1524-9 19646905 - Immunity. 2009 Aug 21;31(2):245-58 14679177 - J Clin Invest. 2003 Dec;112(12):1821-30 23619691 - Nature. 2013 Apr 25;496(7446):445-55 20813258 - Cell. 2010 Sep 3;142(5):687-98 23932714 - Mol Cell. 2013 Aug 8;51(3):310-25 16479018 - J Lipid Res. 2006 May;47(5):1097-111 24337578 - J Biol Chem. 2014 Jan 31;289(5):3001-12 18805087 - Cell. 2008 Sep 19;134(6):933-44 25086775 - Nat Immunol. 2014 Sep;15(9):846-55 24074869 - Cell. 2013 Sep 26;155(1):200-214 20923771 - J Biol Chem. 2010 Dec 17;285(51):39976-85 14580333 - Mol Cell. 2003 Oct;12 (4):805-16 11090130 - Genes Dev. 2000 Nov 15;14 (22):2819-30 20208536 - Nat Genet. 2010 Apr;42(4):343-7 22414897 - Nat Rev Mol Cell Biol. 2012 Mar 14;13(4):213-24 22753953 - J Leukoc Biol. 2012 Oct;92(4):829-39 23096265 - J Pathol. 2013 Jan;229(2):176-85
References_xml	– reference: 22753953 - J Leukoc Biol. 2012 Oct;92(4):829-39 – reference: 14580333 - Mol Cell. 2003 Oct;12 (4):805-16 – reference: 10968783 - Science. 2000 Sep 1;289(5484):1524-9 – reference: 20813258 - Cell. 2010 Sep 3;142(5):687-98 – reference: 19336660 - Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1300-10 – reference: 11090131 - Genes Dev. 2000 Nov 15;14 (22):2831-8 – reference: 19859064 - Nat Rev Immunol. 2009 Oct;9(10):692-703 – reference: 11090130 - Genes Dev. 2000 Nov 15;14 (22):2819-30 – reference: 14679177 - J Clin Invest. 2003 Dec;112(12):1821-30 – reference: 16413480 - Cell. 2006 Jan 13;124(1):35-46 – reference: 23959186 - Nat Immunol. 2013 Sep;14(9):893-900 – reference: 11994399 - J Clin Invest. 2002 May;109(9):1125-31 – reference: 9329978 - J Clin Invest. 1997 Oct 15;100(8):2115-24 – reference: 20208536 - Nat Genet. 2010 Apr;42(4):343-7 – reference: 16479018 - J Lipid Res. 2006 May;47(5):1097-111 – reference: 23535595 - Nature. 2013 Apr 11;496(7444):238-42 – reference: 20498354 - J Immunol. 2010 Jul 1;185(1):605-14 – reference: 26173179 - Elife. 2015 Jul 14;4:e08009 – reference: 21531336 - Cell Metab. 2011 May 4;13(5):540-9 – reference: 18805087 - Cell. 2008 Sep 19;134(6):933-44 – reference: 20513432 - Mol Cell. 2010 May 28;38(4):576-89 – reference: 24833295 - Nat Rev Drug Discov. 2014 Jun;13(6):433-44 – reference: 23746697 - Trends Mol Med. 2013 Aug;19(8):487-500 – reference: 25805830 - FASEB J. 2015 Jul;29(7):2959-69 – reference: 19646905 - Immunity. 2009 Aug 21;31(2):245-58 – reference: 24074869 - Cell. 2013 Sep 26;155(1):200-214 – reference: 24337578 - J Biol Chem. 2014 Jan 31;289(5):3001-12 – reference: 22414897 - Nat Rev Mol Cell Biol. 2012 Mar 14;13(4):213-24 – reference: 25086775 - Nat Immunol. 2014 Sep;15(9):846-55 – reference: 21041726 - J Immunol. 2010 Dec 1;185(11):6599-607 – reference: 19299558 - Genes Dev. 2009 Mar 15;23 (6):681-93 – reference: 23332752 - Cell. 2013 Jan 17;152(1-2):157-71 – reference: 23932714 - Mol Cell. 2013 Aug 8;51(3):310-25 – reference: 23096265 - J Pathol. 2013 Jan;229(2):176-85 – reference: 23619691 - Nature. 2013 Apr 25;496(7446):445-55 – reference: 25104388 - Science. 2014 Aug 8;345(6197):679-84 – reference: 18829989 - Diabetes. 2008 Dec;57(12):3239-46 – reference: 12524534 - Nat Med. 2003 Feb;9(2):213-9 – reference: 21106759 - Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21931-6 – reference: 22395709 - Nat Med. 2012 Mar 06;18(3):363-74 – reference: 23307734 - Science. 2013 Jan 11;339(6116):166-72 – reference: 23021221 - Cell. 2012 Sep 28;151(1):138-52 – reference: 26681459 - Nat Immunol. 2016 Jan;17(1):26-33 – reference: 20923771 - J Biol Chem. 2010 Dec 17;285(51):39976-85
SSID	ssj0036393
Score	2.6255627
Snippet	Macrophages play pivotal roles in both the induction and resolution phases of inflammatory processes. Macrophages have been shown to synthesize...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	412
SubjectTerms	Animals Base Sequence Biosynthetic Pathways - drug effects Biosynthetic Pathways - genetics Enhancer Elements, Genetic - genetics Fatty Acids - metabolism Inflammation - genetics Inflammation - pathology Lipid Metabolism - drug effects Lipopolysaccharides - pharmacology Liver X Receptors - metabolism Macrophages - drug effects Macrophages - metabolism Male Mice, Inbred C57BL Phenotype Signal Transduction - drug effects Sterol Regulatory Element Binding Protein 1 - metabolism Time Factors Toll-Like Receptor 4 - metabolism
Title	SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism
URI	https://www.ncbi.nlm.nih.gov/pubmed/28041958 https://www.proquest.com/docview/1854803695
Volume	25
WOSCitedRecordID	wos000396354400021&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEF7UKnjx_agvVvAazXvTk1SxeKgl-KK3sLPZLRWb1CYK_ffOJFFvInjZQ2AhbL6d-WbmywxjZ2kgwYQOWBCkGKCEgHfOM2DZhGghI3CqhNtzXwwG0XDYiZuEW9HIKr9sYmWo01xRjvwC_YofobntBJfTN4umRlF1tRmhschaHlIZknSJ4XcVwUPv69VVZWSRvms3P83U-i410aSldMJz6uJp_0IxK1fTW__vS26wtYZk8m6Nik22oLMttlKPnZxvs5eH-5ur2OHUmaqad6ULXuacMvk1DnlueDzLLUQfAmZSFeL5Y__e5w_jETH3bMRhjhsaddeEHvRkWc55V41TfqdLxNbruJjssKfezeP1rdXMXLAUxhYl2j7q72KnIKXjq0CntgAlqOs8gIhsg_QiRTfv6cj4xhMGoy3pBuCGSgOuqbvLlrI80_uMB-BHylFEiKQPAqQBx4jQGBfQXzqdNjv9OsQEMU2FCpnp_L1Ifo6xzfbqL5FM6-YbiUsNkzpBdPCH3Yds1SUvTCJrccRaBm-0PmbL6qMcF7OTCiy4DuK7T-PKyXw
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=SREBP1+Contributes+to+Resolution+of+Pro-inflammatory+TLR4+Signaling+by+Reprogramming+Fatty+Acid+Metabolism&rft.jtitle=Cell+metabolism&rft.au=Oishi%2C+Yumiko&rft.au=Spann%2C+Nathanael+J&rft.au=Link%2C+Verena+M&rft.au=Muse%2C+Evan+D&rft.date=2017-02-07&rft.issn=1932-7420&rft.eissn=1932-7420&rft.volume=25&rft.issue=2&rft.spage=412&rft_id=info:doi/10.1016%2Fj.cmet.2016.11.009&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-7420&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-7420&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-7420&client=summon