Health-Related Quality of Life is Reduced in Pediatric Multiple Sclerosis

The health-related quality of life of children with multiple sclerosis was compared with that of healthy children and of those with other neurologic diseases. The Pediatric Quality of Life Inventory Version 4.0 was administered to children with multiple sclerosis and clinically isolated syndrome and...

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Vydané v:	Pediatric neurology Ročník 43; číslo 2; s. 97 - 102
Hlavní autori:	Mowry, Ellen M., Julian, Laura J., Im-Wang, Sunny, Chabas, Dorothee, Galvin, Alice J., Strober, Jonathan B., Waubant, Emmanuelle
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York, NY Elsevier Inc 01.08.2010 Elsevier
Predmet:	Adaptation, Psychological - physiology Adolescent Biological and medical sciences Child Child, Preschool Female Health Status Health Status Indicators Humans Male Medical sciences Multiple Sclerosis - psychology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neuromuscular Diseases - psychology Pediatrics Predictive Value of Tests Quality of Life - psychology Self Concept Severity of Illness Index Siblings Surveys and Questionnaires Human Pediatrics Nervous system diseases Multiple sclerosis Central nervous system disease Child Inflammatory disease Quality of life
ISSN:	0887-8994, 1873-5150, 1873-5150
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Abstract	The health-related quality of life of children with multiple sclerosis was compared with that of healthy children and of those with other neurologic diseases. The Pediatric Quality of Life Inventory Version 4.0 was administered to children with multiple sclerosis and clinically isolated syndrome and their parents (proxy reporters) at the University of California, San Francisco (UCSF), Regional Pediatric Multiple Sclerosis Center. Scores were compared with those of siblings and to those of children seen at the UCSF Pediatric Muscular Dystrophy Association Center. After adjustment for age and sex, children with multiple sclerosis or clinically isolated syndrome ( P = 0.003) and their parents ( P = 0.001) reported worse overall health-related quality of life than their siblings. Although overall scores for those with early multiple sclerosis or clinically isolated syndrome were better than for children with neuromuscular disease, their self-reported psychosocial scores were similar. The main predictor of reduced self-reported health-related quality of life among children with multiple sclerosis or clinically isolated syndrome was greater neurologic disability, whereas parents reported worse scores for girls, older children, and those with longer disease duration. Although it is better than for children with chronic neuromuscular diseases, children with multiple sclerosis or clinically isolated syndrome have substantial reductions in health-related quality of life.
AbstractList	The health-related quality of life of children with multiple sclerosis was compared with that of healthy children and of those with other neurologic diseases. The Pediatric Quality of Life Inventory Version 4.0 was administered to children with multiple sclerosis and clinically isolated syndrome and their parents (proxy reporters) at the University of California, San Francisco (UCSF), Regional Pediatric Multiple Sclerosis Center. Scores were compared with those of siblings and to those of children seen at the UCSF Pediatric Muscular Dystrophy Association Center. After adjustment for age and sex, children with multiple sclerosis or clinically isolated syndrome ( P = 0.003) and their parents ( P = 0.001) reported worse overall health-related quality of life than their siblings. Although overall scores for those with early multiple sclerosis or clinically isolated syndrome were better than for children with neuromuscular disease, their self-reported psychosocial scores were similar. The main predictor of reduced self-reported health-related quality of life among children with multiple sclerosis or clinically isolated syndrome was greater neurologic disability, whereas parents reported worse scores for girls, older children, and those with longer disease duration. Although it is better than for children with chronic neuromuscular diseases, children with multiple sclerosis or clinically isolated syndrome have substantial reductions in health-related quality of life. The health-related quality of life of children with multiple sclerosis was compared with that of healthy children and of those with other neurologic diseases. The Pediatric Quality of Life Inventory Version 4.0 was administered to children with multiple sclerosis and clinically isolated syndrome and their parents (proxy reporters) at the University of California, San Francisco (UCSF), Regional Pediatric Multiple Sclerosis Center. Scores were compared with those of siblings and to those of children seen at the UCSF Pediatric Muscular Dystrophy Association Center. After adjustment for age and sex, children with multiple sclerosis or clinically isolated syndrome ( P = 0.003) and their parents ( P = 0.001) reported worse overall health-related quality of life than their siblings. Although overall scores for those with early multiple sclerosis or clinically isolated syndrome were better than for children with neuromuscular disease, their self-reported psychosocial scores were similar. The main predictor of reduced self-reported health-related quality of life among children with multiple sclerosis or clinically isolated syndrome was greater neurologic disability, whereas parents reported worse scores for girls, older children, and those with longer disease duration. Although it is better than for children with chronic neuromuscular diseases, children with multiple sclerosis or clinically isolated syndrome have substantial reductions in health-related quality of life. The health-related quality of life of children with multiple sclerosis was compared with that of healthy children and of those with other neurologic diseases. The Pediatric Quality of Life Inventory Version 4.0 was administered to children with multiple sclerosis and clinically isolated syndrome and their parents (proxy reporters) at the University of California, San Francisco (UCSF), Regional Pediatric Multiple Sclerosis Center. Scores were compared with those of siblings and to those of children seen at the UCSF Pediatric Muscular Dystrophy Association Center. After adjustment for age and sex, children with multiple sclerosis or clinically isolated syndrome (P = 0.003) and their parents (P = 0.001) reported worse overall health-related quality of life than their siblings. Although overall scores for those with early multiple sclerosis or clinically isolated syndrome were better than for children with neuromuscular disease, their self-reported psychosocial scores were similar. The main predictor of reduced self-reported health-related quality of life among children with multiple sclerosis or clinically isolated syndrome was greater neurologic disability, whereas parents reported worse scores for girls, older children, and those with longer disease duration. Although it is better than for children with chronic neuromuscular diseases, children with multiple sclerosis or clinically isolated syndrome have substantial reductions in health-related quality of life.The health-related quality of life of children with multiple sclerosis was compared with that of healthy children and of those with other neurologic diseases. The Pediatric Quality of Life Inventory Version 4.0 was administered to children with multiple sclerosis and clinically isolated syndrome and their parents (proxy reporters) at the University of California, San Francisco (UCSF), Regional Pediatric Multiple Sclerosis Center. Scores were compared with those of siblings and to those of children seen at the UCSF Pediatric Muscular Dystrophy Association Center. After adjustment for age and sex, children with multiple sclerosis or clinically isolated syndrome (P = 0.003) and their parents (P = 0.001) reported worse overall health-related quality of life than their siblings. Although overall scores for those with early multiple sclerosis or clinically isolated syndrome were better than for children with neuromuscular disease, their self-reported psychosocial scores were similar. The main predictor of reduced self-reported health-related quality of life among children with multiple sclerosis or clinically isolated syndrome was greater neurologic disability, whereas parents reported worse scores for girls, older children, and those with longer disease duration. Although it is better than for children with chronic neuromuscular diseases, children with multiple sclerosis or clinically isolated syndrome have substantial reductions in health-related quality of life.
Author	Mowry, Ellen M. Chabas, Dorothee Im-Wang, Sunny Waubant, Emmanuelle Galvin, Alice J. Julian, Laura J. Strober, Jonathan B.
Author_xml	– sequence: 1 givenname: Ellen M. surname: Mowry fullname: Mowry, Ellen M. email: ellen.mowry@ucsf.edu organization: Multiple Sclerosis Center, Department of Neurology, University of California, San Francisco, San Francisco, California – sequence: 2 givenname: Laura J. surname: Julian fullname: Julian, Laura J. organization: Department of Medicine, University of California, San Francisco, San Francisco, California – sequence: 3 givenname: Sunny surname: Im-Wang fullname: Im-Wang, Sunny organization: Multiple Sclerosis Center, Department of Neurology, University of California, San Francisco, San Francisco, California – sequence: 4 givenname: Dorothee surname: Chabas fullname: Chabas, Dorothee organization: Multiple Sclerosis Center, Department of Neurology, University of California, San Francisco, San Francisco, California – sequence: 5 givenname: Alice J. surname: Galvin fullname: Galvin, Alice J. organization: Department of Medicine, University of California, San Francisco, San Francisco, California – sequence: 6 givenname: Jonathan B. surname: Strober fullname: Strober, Jonathan B. organization: Multiple Sclerosis Center, Department of Neurology, University of California, San Francisco, San Francisco, California – sequence: 7 givenname: Emmanuelle surname: Waubant fullname: Waubant, Emmanuelle organization: Multiple Sclerosis Center, Department of Neurology, University of California, San Francisco, San Francisco, California
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Snippet	The health-related quality of life of children with multiple sclerosis was compared with that of healthy children and of those with other neurologic diseases....
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SubjectTerms	Adaptation, Psychological - physiology Adolescent Biological and medical sciences Child Child, Preschool Female Health Status Health Status Indicators Humans Male Medical sciences Multiple Sclerosis - psychology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neuromuscular Diseases - psychology Pediatrics Predictive Value of Tests Quality of Life - psychology Self Concept Severity of Illness Index Siblings Surveys and Questionnaires
Title	Health-Related Quality of Life is Reduced in Pediatric Multiple Sclerosis
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