Health-Related Quality of Life is Reduced in Pediatric Multiple Sclerosis

The health-related quality of life of children with multiple sclerosis was compared with that of healthy children and of those with other neurologic diseases. The Pediatric Quality of Life Inventory Version 4.0 was administered to children with multiple sclerosis and clinically isolated syndrome and...

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Bibliographic Details
Published in:Pediatric neurology Vol. 43; no. 2; pp. 97 - 102
Main Authors: Mowry, Ellen M., Julian, Laura J., Im-Wang, Sunny, Chabas, Dorothee, Galvin, Alice J., Strober, Jonathan B., Waubant, Emmanuelle
Format: Journal Article
Language:English
Published: New York, NY Elsevier Inc 01.08.2010
Elsevier
Subjects:
Adaptation, Psychological - physiology
Adolescent
Biological and medical sciences
Child
Child, Preschool
Female
Health Status
Health Status Indicators
Humans
Male
Medical sciences
Multiple Sclerosis - psychology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Neuromuscular Diseases - psychology
Pediatrics
Predictive Value of Tests
Quality of Life - psychology
Self Concept
Severity of Illness Index
Siblings
Surveys and Questionnaires
Human
Pediatrics
Nervous system diseases
Multiple sclerosis
Central nervous system disease
Child
Inflammatory disease
Quality of life
ISSN:0887-8994, 1873-5150, 1873-5150
Online Access:Get full text
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Summary:The health-related quality of life of children with multiple sclerosis was compared with that of healthy children and of those with other neurologic diseases. The Pediatric Quality of Life Inventory Version 4.0 was administered to children with multiple sclerosis and clinically isolated syndrome and their parents (proxy reporters) at the University of California, San Francisco (UCSF), Regional Pediatric Multiple Sclerosis Center. Scores were compared with those of siblings and to those of children seen at the UCSF Pediatric Muscular Dystrophy Association Center. After adjustment for age and sex, children with multiple sclerosis or clinically isolated syndrome ( P = 0.003) and their parents ( P = 0.001) reported worse overall health-related quality of life than their siblings. Although overall scores for those with early multiple sclerosis or clinically isolated syndrome were better than for children with neuromuscular disease, their self-reported psychosocial scores were similar. The main predictor of reduced self-reported health-related quality of life among children with multiple sclerosis or clinically isolated syndrome was greater neurologic disability, whereas parents reported worse scores for girls, older children, and those with longer disease duration. Although it is better than for children with chronic neuromuscular diseases, children with multiple sclerosis or clinically isolated syndrome have substantial reductions in health-related quality of life.
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ISSN:0887-8994
1873-5150
1873-5150
DOI:10.1016/j.pediatrneurol.2010.03.007