Glioblastoma of the cerebellum and brainstem

Glioblastoma multiforme (GB) is the most common and most malignant primary intracranial tumor. Of the 577 patients who underwent surgery for newly diagnosed GB (World Health Organization grade IV) between January 1991 and March 2008 at our department, seven had infratentorial GB (iGB) (incidence 1.2...

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Vydané v:	Journal of clinical neuroscience Ročník 17; číslo 10; s. 1248 - 1251
Hlavní autori:	Stark, Andreas Martin, Maslehaty, Homajoun, Hugo, Heinz Hermann, Mahvash, Mehran, Mehdorn, Hubertus Maximilian
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Scotland Elsevier Ltd 01.10.2010
Predmet:	Adjuvants Adult Aged Aged, 80 and over Brain Neoplasms - pathology Brain Neoplasms - surgery Brain Stem - pathology Brain Stem - surgery Brainstem glioma Cerebellum - pathology Cerebellum - surgery Cerebellum glioma Female Glioblastoma - pathology Glioblastoma - surgery Glioblastoma multiforme Humans Infratentorial glioblastoma Magnetic Resonance Imaging - methods Male Middle Aged Neurology Retrospective Studies Young Adult Infratentorial glioblastoma Brainstem glioma Cerebellum glioma Glioblastoma multiforme
ISSN:	0967-5868, 1532-2653, 1532-2653
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Popis
Shrnutí:	Glioblastoma multiforme (GB) is the most common and most malignant primary intracranial tumor. Of the 577 patients who underwent surgery for newly diagnosed GB (World Health Organization grade IV) between January 1991 and March 2008 at our department, seven had infratentorial GB (iGB) (incidence 1.2%). Patients younger than 21 years of age, as well as patients with gliomatosis cerebri, were excluded from the analysis. We concluded that iGB is rare in adults. Because of its rarity and the non-specific radiological features of iGB, it can easily be misdiagnosed as a brain metastasis, ependymoma or even as a benign lesion such as vestibular schwannoma or meningioma. Surgical removal, or at least stereotactic biopsy, is essential to establish the diagnosis. Postoperative adjuvant therapy similar to that for supratentorial glioblastoma is indicated. We analysed the clinical characteristics and therapy of our patients with iGB and reviewed the literature.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0967-5868 1532-2653 1532-2653
DOI:	10.1016/j.jocn.2010.02.015