Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes

The cytoprotective effects of activated protein C (aPC) are well established. In contrast, the receptors and signaling mechanism through which aPC conveys cytoprotection in various cell types remain incompletely defined. Thus, within the renal glomeruli, aPC preserves endothelial cells via a proteas...

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Veröffentlicht in:	Blood Jg. 119; H. 3; S. 874
Hauptverfasser:	Madhusudhan, Thati, Wang, Hongjie, Straub, Beate K, Gröne, Elisabeth, Zhou, Qianxing, Shahzad, Khurrum, Müller-Krebs, Sandra, Schwenger, Vedat, Gerlitz, Bruce, Grinnell, Brian W, Griffin, John H, Reiser, Jochen, Gröne, Hermann-Josef, Esmon, Charles T, Nawroth, Peter P, Isermann, Berend
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 19.01.2012
Schlagworte:	Animals Anticoagulants - metabolism Apoptosis Cell Communication Cells, Cultured Cytoprotection Humans Kidney Glomerulus - cytology Kidney Glomerulus - metabolism Lipopolysaccharides - pharmacology Membrane Microdomains Mice Podocytes - drug effects Podocytes - metabolism Podocytes - pathology Protein C - metabolism Protein Multimerization Receptor, PAR-1 - metabolism Receptors, Thrombin - metabolism Signal Transduction Thrombin
ISSN:	1528-0020, 1528-0020
Online-Zugang:	Weitere Angaben
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