Viral receptor-binding site antibodies with diverse germline origins

Vaccines for rapidly evolving pathogens will confer lasting immunity if they elicit antibodies recognizing conserved epitopes, such as a receptor-binding site (RBS). From characteristics of an influenza-virus RBS-directed antibody, we devised a signature motif to search for similar antibodies. We id...

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Bibliographic Details

Published in:	Cell Vol. 161; no. 5; pp. 1026 - 1034
Main Authors:	Schmidt, Aaron G, Therkelsen, Matthew D, Stewart, Shaun, Kepler, Thomas B, Liao, Hua-Xin, Moody, M Anthony, Haynes, Barton F, Harrison, Stephen C
Format:	Journal Article
Language:	English
Published:	United States 21.05.2015
Subjects:	Amino Acid Sequence Antibodies, Viral - chemistry Antibodies, Viral - immunology Complementarity Determining Regions Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Influenza Vaccines - immunology Models, Molecular Molecular Mimicry Molecular Sequence Data Receptors, Virus - chemistry
ISSN:	1097-4172
Online Access:	Get more information
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