The Relationship Between Number of Medications and Weight Loss or Impaired Balance in Older Adults

Objectives: To examine the relationship between cumulative medication exposure and risk of two common manifestations of adverse drug effects: weight loss and impaired balance. Design: Cross‐sectional and longitudinal cohort. Setting: Urban Connecticut community. Participants: Eight hundred eighty‐fi...

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Vydané v:	Journal of the American Geriatrics Society (JAGS) Ročník 52; číslo 10; s. 1719 - 1723
Hlavní autori:	Agostini, Joseph V., Han, Ling, Tinetti, Mary E.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Oxford, UK Blackwell Science Inc 01.10.2004 Blackwell Wiley Subscription Services, Inc
Predmet:	Adjustment Adults adverse effects Aged Balance Biological and medical sciences Chronic illnesses Cognitive impairment Confidence Intervals Connecticut Coordination Cross-Sectional Studies Disease Drug abuse Drug effects Drug Therapy - statistics & numerical data Drug-Related Side Effects and Adverse Reactions Drugs Elderly people Female General aspects Geriatrics Health risk assessment Health Status Hearing disorders Hearing loss Humans Male Medical sciences Medical treatment Mental depression Multiple drugs Older people Pharmacoepidemiology Postural Balance - drug effects Prescription drugs Risk factors Side effects USA Weight Weight loss Weight Loss - drug effects Connecticut Human Drug Gerontology Weight loss Balance Elderly Geriatrics
ISSN:	0002-8614, 1532-5415
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Popis
Shrnutí:	Objectives: To examine the relationship between cumulative medication exposure and risk of two common manifestations of adverse drug effects: weight loss and impaired balance. Design: Cross‐sectional and longitudinal cohort. Setting: Urban Connecticut community. Participants: Eight hundred eighty‐five community‐dwelling residents aged 72 and older. Measurements: Weight loss (≥10 pounds) and balance, a composite of four balance measures. Results: Participants took a mean±standard deviation of 2.2±1.9 medications (range 0–15). After adjustment for age, depressive symptoms, cognitive impairment, vision and hearing impairments, number of chronic diseases, and number of hospitalizations in the previous year, the adjusted odds ratio (OR) for weight loss was 1.48 (95% confidence interval (CI)=0.85–2.59) for those taking one to two medications, 1.96 (95% CI=1.08–3.54) for three to four medications, and 2.78 (95% CI=1.38–5.60) for five or more medications. For impaired balance, adjusted ORs were 1.44 (95% CI=0.94–2.19), 1.72 (95% CI=1.09–2.71), and 1.80 (95% CI=1.02–3.19), respectively. Conclusion: A greater number of medications were associated with increased risk of adverse drug outcomes, after extensive adjustment for chronic illness. Clinicians should consider the adverse effects of total drug use and not merely the benefits or risks of individual medications for specific diseases.
Bibliografia:	ark:/67375/WNG-7M49HV1L-R istex:6DD612E3BD87E2A0DAEB8C34966C42E6E362BDCA ArticleID:JGS52467 Supported by the Patrick and Catherine Weldon Donaghue Medical Research Foundation and the Claude D. Pepper Older Americans Independence Center (P60AG10469) from the National Institute on Aging. Dr. Agostini was a Robert Wood Johnson Clinical Scholar, sponsored by the Veterans Administration, during the time of this work. SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
ISSN:	0002-8614 1532-5415
DOI:	10.1111/j.1532-5415.2004.52467.x