Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

The authors report the first-in-human application of personalized neo-antigen RNA vaccines in patients with melanoma. Personalized cancer vaccine trials Neoantigens have long been considered optimal targets for anti-tumour vaccines, and recent mutation coding and prediction techniques have aimed to...

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Veröffentlicht in:	Nature (London) Jg. 547; H. 7662; S. 222 - 226
Hauptverfasser:	Sahin, Ugur, Derhovanessian, Evelyna, Miller, Matthias, Kloke, Björn-Philipp, Simon, Petra, Löwer, Martin, Bukur, Valesca, Tadmor, Arbel D., Luxemburger, Ulrich, Schrörs, Barbara, Omokoko, Tana, Vormehr, Mathias, Albrecht, Christian, Paruzynski, Anna, Kuhn, Andreas N., Buck, Janina, Heesch, Sandra, Schreeb, Katharina H., Müller, Felicitas, Ortseifer, Inga, Vogler, Isabel, Godehardt, Eva, Attig, Sebastian, Rae, Richard, Breitkreuz, Andrea, Tolliver, Claudia, Suchan, Martin, Martic, Goran, Hohberger, Alexander, Sorn, Patrick, Diekmann, Jan, Ciesla, Janko, Waksmann, Olga, Brück, Alexandra-Kemmer, Witt, Meike, Zillgen, Martina, Rothermel, Andree, Kasemann, Barbara, Langer, David, Bolte, Stefanie, Diken, Mustafa, Kreiter, Sebastian, Nemecek, Romina, Gebhardt, Christoffer, Grabbe, Stephan, Höller, Christoph, Utikal, Jochen, Huber, Christoph, Loquai, Carmen, Türeci, Özlem
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 13.07.2017 Nature Publishing Group
Schlagworte:	13 13/106 13/107 13/21 13/31 13/51 631/250/251/1567 631/67/1059/2325 692/308/153 692/308/2779/109/1940 692/308/575 Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antigens B7-H1 Antigen - immunology beta 2-Microglobulin - deficiency Cancer Cancer Vaccines - genetics Cancer Vaccines - immunology Cancer Vaccines - therapeutic use CD8 Antigens - immunology Epitopes Epitopes - genetics Epitopes - immunology Genetic aspects Genomics Health aspects Humanities and Social Sciences Humans Immunity Immunotherapy Immunotherapy - methods Infiltration letter Lymphocytes Lymphocytes T Melanoma Melanoma - genetics Melanoma - immunology Melanoma - therapy Metastases Metastasis Methods multidisciplinary Mutation Mutation - genetics Neoplasm Metastasis Neoplasm Recurrence, Local - prevention & control Patients PD-1 protein Precision medicine Precision Medicine - methods Prevention Programmed Cell Death 1 Receptor - antagonists & inhibitors Ribonucleic acid RNA RNA - genetics Science T cell receptors T-Lymphocytes - immunology Tumors Vaccination Vaccines
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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