Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models

Variants of TREM2 are associated with Alzheimer's disease (AD). To study whether increasing TREM2 gene dosage could modify the disease pathogenesis, we developed BAC transgenic mice expressing human TREM2 (BAC-TREM2) in microglia. We found that elevated TREM2 expression reduced amyloid burden i...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Jg. 97; H. 5; S. 1032
Hauptverfasser:	Lee, C Y Daniel, Daggett, Anthony, Gu, Xiaofeng, Jiang, Lu-Lin, Langfelder, Peter, Li, Xiaoguang, Wang, Nan, Zhao, Yingjun, Park, Chang Sin, Cooper, Yonatan, Ferando, Isabella, Mody, Istvan, Coppola, Giovanni, Xu, Huaxi, Yang, X William
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 07.03.2018
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - pathology Animals Animals, Newborn Cells, Cultured Cellular Reprogramming Techniques - methods Disease Models, Animal Female Gene Dosage - genetics Humans Male Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Memory - physiology Mice Mice, Inbred C57BL Mice, Transgenic Microglia - pathology Microglia - physiology Organ Culture Techniques Phenotype Receptors, Immunologic - biosynthesis Receptors, Immunologic - genetics RNA-sequencing reprogramming mouse Alzheimer’s disease BAC neuroinflammation TREM2 amyloid plaque gene dosage microglia
ISSN:	1097-4199, 1097-4199
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