Targeting the Tumor Immune Microenvironment Could Become a Potential Therapeutic Modality for Aggressive Pituitary Adenoma

Object: This study aimed to explore the relationship between the aggressiveness and immune cell infiltration in pituitary adenoma (PA) and to provide the basis for immuno-targeting therapies. Methods: One hundred and three patients with PA who underwent surgery at a single institution were retrospec...

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Vydáno v:Brain sciences Ročník 13; číslo 2; s. 164
Hlavní autoři: Yang, Zuocheng, Tian, Xuemei, Yao, Kun, Yang, Yakun, Zhang, Linpeng, Liu, Ning, Yan, Changxiang, Qi, Xueling, Han, Song
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 18.01.2023
MDPI
Témata:
Adenoma
aggressive pituitary adenoma
Angiogenesis
Antibodies
Brain cancer
CD163 antigen
CD8 antigen
CD8+ TILs
combined immunotherapy
Gelatinase B
Health aspects
immune microenvironment
Immunotherapy
Infiltration
Lymphocytes T
macrophage
Macrophages
Magnetic resonance imaging
Medical imaging
Medical prognosis
Medical research
Metastases
Microenvironments
Neuroimaging
PD-L1 protein
Pituitary
Pituitary gland tumors
Software
temozolomide
Tumor proteins
Tumor-infiltrating lymphocytes
Tumors
China
United States > US
temozolomide
CD8+ TILs
aggressive pituitary adenoma
macrophage
immune microenvironment
combined immunotherapy
ISSN:2076-3425, 2076-3425
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Shrnutí:Object: This study aimed to explore the relationship between the aggressiveness and immune cell infiltration in pituitary adenoma (PA) and to provide the basis for immuno-targeting therapies. Methods: One hundred and three patients with PA who underwent surgery at a single institution were retrospectively identified. The infiltration of macrophages and T-lymphocytes was quantitatively assessed. Results: The number of CD68+ macrophages was positively correlated with Knosp (p = 0.003) and MMP-9 expression grades (p = 0.00). The infiltration of CD163+ macrophages differed among Knosp (p = 0.022) and MMP-9 grades (p = 0.04). CD8+ tumor-infiltrating lymphocytes (TILs) were also positively associated with Knosp (p = 0.002) and MMP-9 grades (p = 0.01). Interestingly, MGMT expression was positively correlated with MMP-9 staining extent (p = 0.000). The quantities of CD8+ TILs (p = 0.016), CD68+ macrophages (p = 0.000), and CD163+ macrophages (p = 0.043) were negatively associated with MGMT expression levels. The number of CD68+ macrophages in the PD-L1 negative group was significantly more than that in the PD-L1 positive group (p = 0.01). The rate of PD-L1 positivity was positively correlated with the Ki-67 index (p = 0.046) and p53 expression (p = 0.029). Conclusion: Targeted therapy for macrophages and CD8+ TILs could be a helpful treatment in the future for aggressive PA. Anti-PD-L1 therapy may better respond to PAs with higher Ki-67 and p53 expression and more infiltrating CD68+ macrophages. Multiple treatment modalities, especially combined with immunotherapy could become a novel therapeutic strategy for aggressive PA.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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These authors contributed equally to this work.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci13020164