Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus

Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cel...

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Published in:Neuron (Cambridge, Mass.) Vol. 93; no. 3; p. 677
Main Authors: GoodSmith, Douglas, Chen, Xiaojing, Wang, Cheng, Kim, Sang Hoon, Song, Hongjun, Burgalossi, Andrea, Christian, Kimberly M, Knierim, James J
Format: Journal Article
Language:English
Published: United States 08.02.2017
Subjects:
Action Potentials - physiology
Animals
Brain Mapping
CA3 Region, Hippocampal - cytology
CA3 Region, Hippocampal - physiology
Decision Trees
Dentate Gyrus - cytology
Dentate Gyrus - physiology
Exploratory Behavior - physiology
Interneurons - cytology
Interneurons - physiology
Memory
Models, Neurological
Mossy Fibers, Hippocampal - physiology
Neurons - cytology
Neurons - physiology
Pyramidal Cells - cytology
Pyramidal Cells - physiology
Rats
Rats, Long-Evans
Spatial Processing - physiology
dentate gyrus
pattern separation
hilus
mossy cell
granule cell
ISSN:1097-4199, 1097-4199
Online Access:Get more information
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Summary:Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneurons, but the influence of mossy cells on dentate function is often overlooked. Multiple tetrode recordings, supported by juxtacellular recording techniques, showed that granule cells fired very sparsely, whereas mossy cells in the hilus fired promiscuously in multiple locations and in multiple environments. The activity patterns of these cell types thus represent different environments through distinct computational mechanisms: sparse coding in granule cells and changes in firing field locations in mossy cells.
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ISSN:1097-4199
1097-4199
DOI:10.1016/j.neuron.2016.12.026