The L1 retrotransposition assay: A retrospective and toolkit

LINE1s (L1s) are a class of mammalian non-LTR (long terminal repeat) retroelements that make up nearly 20% of the human genome. Because of the difficulty of studying the mobilization of endogenous L1s, an exogenous cell culture retrotransposition assay has become integral to research in L1 biology....

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Bibliographic Details
Published in:	Methods (San Diego, Calif.) Vol. 49; no. 3; pp. 219 - 226
Main Authors:	Rangwala, Sanjida H., Kazazian, Haig H.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.11.2009
Subjects:	Animals Cell culture assays Cell Culture Techniques Cell Line Chickens Cricetinae Genetic Techniques Humans LINE1 (L1) Long Interspersed Nucleotide Elements - physiology Mice Models, Genetic Mutagenesis, Insertional Non-LTR retrotransposons Rats Retrotransposition Transgenic mice LINE1 (L1) Cell culture assays Retrotransposition Non-LTR retrotransposons Transgenic mice
ISSN:	1046-2023, 1095-9130, 1095-9130
Online Access:	Get full text
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