Lamin in inflammation and aging

Aging is characterized by a progressive loss of tissue function and an increased susceptibility to injury and disease. Many age-associated pathologies manifest an inflammatory component, and this has led to the speculation that aging is at least in part caused by some form of inflammation. However,...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Current opinion in cell biology Ročník 40; s. 124 - 130
Hlavní autoři: Tran, Joseph R, Chen, Haiyang, Zheng, Xiaobin, Zheng, Yixian
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Elsevier Ltd 01.06.2016
Témata:
Aging - immunology
Aging - pathology
Animals
Drosophila
Fat Body - metabolism
Humans
Inflammation - immunology
Inflammation - pathology
Internal Medicine
Lamin Type B - metabolism
ISSN:0955-0674, 1879-0410, 1879-0410
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Aging is characterized by a progressive loss of tissue function and an increased susceptibility to injury and disease. Many age-associated pathologies manifest an inflammatory component, and this has led to the speculation that aging is at least in part caused by some form of inflammation. However, whether or not inflammation is truly a cause of aging, or is a consequence of the aging process is unknown. Recent work using Drosophila has uncovered a mechanism where the progressive loss of lamin-B in the fat body upon aging triggers systemic inflammation. This inflammatory response perturbs the local immune response of the neighboring gut tissue and leads to hyperplasia. Here, we will discuss the literature connecting lamins to aging and inflammation.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0955-0674
1879-0410
1879-0410
DOI:10.1016/j.ceb.2016.03.004