Treatment of Inflammatory Bowel Disease: A Comprehensive Review

Inflammatory bowel disease (IBD), as a global disease, has attracted much research interest. Constant research has led to a better understanding of the disease condition and further promoted its management. We here reviewed the conventional and the novel drugs and therapies, as well as the potential...

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Published in:Frontiers in medicine Vol. 8; p. 765474
Main Authors: Cai, Zhaobei, Wang, Shu, Li, Jiannan
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media SA 20.12.2021
Frontiers Media S.A
Subjects:
Acids
Apheresis
Biological products
Colorectal cancer
Crohn disease
Crohn's disease
Drug dosages
Endoscopy
Immunomodulators
Inflammatory bowel disease
Kinases
Medicine
Meta-analysis
Microbiota
recent advance
Remission (Medicine)
Side effects
Steroids
Surgery
Systematic review
therapeutics
TNF inhibitors
Tumor necrosis factor-TNF
ulcerative colitis
Crohn disease
therapeutics
ulcerative colitis
recent advance
inflammatory bowel disease
ISSN:2296-858X, 2296-858X
Online Access:Get full text
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Summary:Inflammatory bowel disease (IBD), as a global disease, has attracted much research interest. Constant research has led to a better understanding of the disease condition and further promoted its management. We here reviewed the conventional and the novel drugs and therapies, as well as the potential ones, which have shown promise in preclinical studies and are likely to be effective future therapies. The conventional treatments aim at controlling symptoms through pharmacotherapy, including aminosalicylates, corticosteroids, immunomodulators, and biologics, with other general measures and/or surgical resection if necessary. However, a considerable fraction of patients do not respond to available treatments or lose response, which calls for new therapeutic strategies. Diverse therapeutic options are emerging, involving small molecules, apheresis therapy, improved intestinal microecology, cell therapy, and exosome therapy. In addition, patient education partly upgrades the efficacy of IBD treatment. Recent advances in the management of IBD have led to a paradigm shift in the treatment goals, from targeting symptom-free daily life to shooting for mucosal healing. In this review, the latest progress in IBD treatment is summarized to understand the advantages, pitfalls, and research prospects of different drugs and therapies and to provide a basis for the clinical decision and further research of IBD.
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This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine
Edited by: Giulia Roda, Humanitas University, Italy
These authors have contributed equally to this work
Reviewed by: Isabella Dotti, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Spain; Zhao Ding, Wuhan University, China; Xiaoli Rong, The Johns Hopkins Hospital, Johns Hopkins Medicine, United States
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2021.765474