Expression of voltage-dependent potassium channels in first trimester human placentae

Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental...

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Bibliographic Details
Published in:Placenta (Eastbourne) Vol. 35; no. 5; pp. 337 - 340
Main Authors: Mistry, H.D., Kurlak, L.O., Whitley, G.S., Cartwright, J.E., Broughton Pipkin, F., Tribe, R.M.
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 01.05.2014
Elsevier
Subjects:
Adult
Biological and medical sciences
Early pregnancy
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Humans
Internal Medicine
KCNE
KCNQ
Obstetrics and Gynecology
Placenta
Placenta - metabolism
Potassium channel
Potassium Channels, Voltage-Gated - genetics
Potassium Channels, Voltage-Gated - metabolism
Pregnancy
Pregnancy Trimester, First - genetics
Pregnancy Trimester, First - metabolism
KCNQ
Early pregnancy
Placenta
KCNE
Potassium channel
Pregnancy
Human
Vertebrata
Mammalia
First trimester
Ionic channel
Inorganic element
Potassium
ISSN:0143-4004, 1532-3102, 1532-3102
Online Access:Get full text
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Summary:Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at ≤10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P = 0.022). This novel study reports mRNA and protein expression of KV7 channels in first trimester placentae.
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ISSN:0143-4004
1532-3102
1532-3102
DOI:10.1016/j.placenta.2014.02.008