Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome

The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series. The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS. The Survey on Arrhythmic Events in Brugada...

Full description

Saved in:
Bibliographic Details
Published in:Heart rhythm Vol. 15; no. 9; p. 1394
Main Authors: Michowitz, Yoav, Milman, Anat, Sarquella-Brugada, Georgia, Andorin, Antoine, Champagne, Jean, Postema, Pieter G, Casado-Arroyo, Ruben, Leshem, Eran, Juang, Jimmy J M, Giustetto, Carla, Tfelt-Hansen, Jacob, Wijeyeratne, Yanushi D, Veltmann, Christian, Corrado, Domenico, Kim, Sung-Hwan, Delise, Pietro, Maeda, Shingo, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Hochstadt, Aviram, Mizusawa, Yuka, Rahkovich, Michael, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Napolitano, Carlo, Brugada, Ramon, Calo, Leonardo, Priori, Silvia G, Takagi, Masahiko, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard
Format: Journal Article
Language:English
Published: United States 01.09.2018
Subjects:
Adolescent
Adult
Aged
Brugada Syndrome - complications
Brugada Syndrome - physiopathology
Child
Child, Preschool
Electrocardiography
Female
Fever - complications
Humans
Infant
Infant, Newborn
Male
Middle Aged
Prognosis
Surveys and Questionnaires
Ventricular Fibrillation - etiology
Ventricular Fibrillation - physiopathology
Young Adult
Ethnicity
Children
Brugada syndrome
Elderly
Fever
Sex
ISSN:1556-3871, 1556-3871
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series. The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS. The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n = 252). In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 ± 24 years (range 0.3-76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0-5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years. The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1556-3871
1556-3871
DOI:10.1016/j.hrthm.2018.04.007