Bidirectional crosstalk between epithelial–mesenchymal plasticity and IFN γ -induced PD-L1 expression promotes tumour progression

Epithelial–mesenchymal transition (EMT) and immunoevasion through upregulation of programmed death-ligand 1 (PD-L1) are important drivers of cancer progression. While EMT has been proposed to facilitate PD-L1-mediated immunosuppression, molecular mechanisms of their interaction remain obscure. Here,...

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Veröffentlicht in:	Royal Society open science Jg. 9; H. 11; S. 220186
Hauptverfasser:	Burger, Gerhard A., Nesenberend, Daphne N., Lems, Carlijn M., Hille, Sander C., Beltman, Joost B.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	The Royal Society 02.11.2022
Schlagworte:	Biochemistry, Cellular and Molecular Biology epithelial-mesenchymal transition (EMT) immune evasion interferon gamma PD-L1
ISSN:	2054-5703, 2054-5703
Online-Zugang:	Volltext
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