A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

Identifying cellular factors that determine susceptibility to infection can help us understand how Ebola virus is transmitted. We asked if the EBOV receptor Niemann-Pick C1 (NPC1) could explain why reptiles are resistant to EBOV infection. We demonstrate that cells derived from the Russell’s viper a...

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Bibliographic Details
Published in:	mSphere Vol. 1; no. 2
Main Authors:	Ndungo, Esther, Herbert, Andrew S., Raaben, Matthijs, Obernosterer, Gregor, Biswas, Rohan, Miller, Emily Happy, Wirchnianski, Ariel S., Carette, Jan E., Brummelkamp, Thijn R., Whelan, Sean P., Dye, John M., Chandran, Kartik
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01.03.2016
Subjects:	Ebola virus endosomal receptor filovirus intracellular receptor Niemann-Pick C1 NPC1 Outbreaks Ebola virus Niemann-Pick C1 virus-host interactions NPC1 reptiles viral receptor endosomal receptor filovirus intracellular receptor
ISSN:	2379-5042, 2379-5042
Online Access:	Get full text
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