The Success and Failure of the Schwann Cell Response to Nerve Injury

The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin) and myelin phenotypes, which are specialized to meet the needs of small and large diameter axons, and differ markedly from each other. It also enables Schwann cells initially to mount a strikingly adaptive respons...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Frontiers in cellular neuroscience Ročník 13; s. 33
Hlavní autori: Jessen, Kristjan R., Mirsky, Rhona
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Research Foundation 11.02.2019
Frontiers Media S.A
Predmet:
c-Jun
Cell adhesion & migration
Fibroblasts
Genotype & phenotype
Myelin
nerve injury
Neuroscience
Neurosciences
Peripheral nerves
Phenotypes
PNS
Proteins
re-programming
Regeneration
repair cell
Schwann cells
Steam
Transcription factors
c-Jun
PNS
Schwann cell
regeneration
nerve injury
re-programming
repair cell
ISSN:1662-5102, 1662-5102
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin) and myelin phenotypes, which are specialized to meet the needs of small and large diameter axons, and differ markedly from each other. It also enables Schwann cells initially to mount a strikingly adaptive response to nerve injury and to promote regeneration by converting to a repair-promoting phenotype. These repair cells activate a sequence of supportive functions that engineer myelin clearance, prevent neuronal death, and help axon growth and guidance. Eventually, this response runs out of steam, however, because in the long run the phenotype of repair cells is unstable and their survival is compromised. The re-programming of Remak and myelin cells to repair cells, together with the injury-induced switch of peripheral neurons to a growth mode, gives peripheral nerves their strong regenerative potential. But it remains a challenge to harness this potential and devise effective treatments that maintain the initial repair capacity of peripheral nerves for the extended periods typically required for nerve repair in humans.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
Edited by: Esther Udina, Autonomous University of Barcelona, Spain
Reviewed by: Valerio Magnaghi, University of Milan, Italy; Edgar Richard Kramer, Plymouth University, United Kingdom
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2019.00033