Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19

A recent report found that rare predicted loss-of-function (pLOF) variants across 13 candidate genes in TLR3- and IRF-7 dependent type I IFN pathways explain up to 3.5% of severe COVID-19 cases. We performed whole-exome or whole genome sequencing of 1,864 COVID-19 cases (713 with severe and 1,151 wi...

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Bibliographic Details

Published in:	The Journal of clinical investigation Vol. 131; no. 14
Main Authors:	Povysil, Gundula, Butler-Laporte, Guillaume, Shang, Ning, Wang, Chen, Khan, Atlas, Alaamery, Manal, Nakanishi, Tomoko, Zhou, Sirui, Forgetta, Vincenzo, Eveleigh, Robert J.M., Bourgey, Mathieu, Aziz, Naveed, Jones, Steven J.M., Knoppers, Bartha, Scherer, Stephen W., Strug, Lisa J., Lepage, Pierre, Ragoussis, Jiannis, Bourque, Guillaume, Alghamdi, Jahad, Aljawini, Nora, Albes, Nour, Al-Afghani, Hani M., Alghamdi, Bader, Almutairi, Mansour S., Mahmoud, Ebrahim Sabri, Abu-Safieh, Leen, El Bardisy, Hadeel, Harthi, Fawz S. Al, Alshareef, Abdulraheem, Suliman, Bandar Ali, Alqahtani, Saleh A., Almalik, Abdulaziz, Alrashed, May M., Massadeh, Salam, Mooser, Vincent, Lathrop, Mark, Fawzy, Mohamed, Arabi, Yaseen M., Mbarek, Hamdi, Saad, Chadi, Al-Muftah, Wadha, Jung, Junghyun, Mangul, Serghei, Badji, Radja, Thani, Asma Al, Ismail, Said I., Gharavi, Ali G., Abedalthagafi, Malak S., Richards, J. Brent, Goldstein, David B., Kiryluk, Krzysztof
Format:	Journal Article
Language:	English
Published:	American Society for Clinical Investigation 15.07.2021
Subjects:	Concise Communication Genetic aspects Genetic research Genetic variation Health aspects Interferon United States
ISSN:	1558-8238, 0021-9738, 1558-8238
Online Access:	Get full text
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