The Role of BDNF on Neural Plasticity in Depression

Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. Meanwhile, functions of the brain-derived neurotr...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Frontiers in cellular neuroscience Ročník 14; s. 82
Hlavní autoři:	Yang, Tao, Nie, Zheng, Shu, Haifeng, Kuang, Yongqin, Chen, Xin, Cheng, Jingmin, Yu, Sixun, Liu, Huiying
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland Frontiers Research Foundation 15.04.2020 Frontiers Media S.A
Témata:	Amygdala Apoptosis BDNF Behavioral plasticity Brain-derived neurotrophic factor Cellular Neuroscience depression Drug therapy Gene expression Hypotheses Intracellular signalling Kinases Ligands Mental depression Neostriatum neural plasticity Neurogenesis Neurons Neurotrophic factors Phosphorylation Plasticity (neural) Prefrontal cortex Proteins Transcription neurogenesis depression BDNF neural plasticity neurotrophic factors
ISSN:	1662-5102, 1662-5102
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. Meanwhile, functions of the brain-derived neurotrophic factor (BDNF) and the other neurotrophins in the pathogenesis of depression are well known. The maladaptive neuroplastic in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of neurotrophic factors signaling has great potential in therapy for depression. This review highlights the relevance of neurotrophic factors mediated neural plasticity and pathophysiology of depression. These studies reviewed here may suggest new possible targets for antidepressant drugs such as neurotrophins, their receptors, and relevant signaling pathways, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophic factors in the brain.
AbstractList	Recent studies combining pharmacological, behavioral, electrophysiological and molecular approaches indicate that depression results from maladaptive neuroplastic processes occurring in defined frontolimbic circuits responsible for emotional processing such as the prefrontal cortex, hippocampus, amygdala and ventral striatum. Meanwhile, the role of the brain-derived neurotrophic factor and the other neurotrophins in the pathophysiology of depression is well known. The abnormal neural plasticity in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of neurotrophic factors signaling has great potential in therapy for depression. This review highlights the relevance of neurotrophic factors mediated neural plasticity and pathophysiology of depression. These studies reviewed here may suggest new possible targets for the pharmacotherapy of depression such as neurotrophic factors, their receptors and related intracellular signaling cascades, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophins in the brain. Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. Meanwhile, functions of the brain-derived neurotrophic factor (BDNF) and the other neurotrophins in the pathogenesis of depression are well known. The maladaptive neuroplastic in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of neurotrophic factors signaling has great potential in therapy for depression. This review highlights the relevance of neurotrophic factors mediated neural plasticity and pathophysiology of depression. These studies reviewed here may suggest new possible targets for antidepressant drugs such as neurotrophins, their receptors, and relevant signaling pathways, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophic factors in the brain. Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. Meanwhile, functions of the brain-derived neurotrophic factor (BDNF) and the other neurotrophins in the pathogenesis of depression are well known. The maladaptive neuroplastic in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of neurotrophic factors signaling has great potential in therapy for depression. This review highlights the relevance of neurotrophic factors mediated neural plasticity and pathophysiology of depression. These studies reviewed here may suggest new possible targets for antidepressant drugs such as neurotrophins, their receptors, and relevant signaling pathways, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophic factors in the brain.Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. Meanwhile, functions of the brain-derived neurotrophic factor (BDNF) and the other neurotrophins in the pathogenesis of depression are well known. The maladaptive neuroplastic in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of neurotrophic factors signaling has great potential in therapy for depression. This review highlights the relevance of neurotrophic factors mediated neural plasticity and pathophysiology of depression. These studies reviewed here may suggest new possible targets for antidepressant drugs such as neurotrophins, their receptors, and relevant signaling pathways, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophic factors in the brain.
Author	Chen, Xin Cheng, Jingmin Liu, Huiying Yang, Tao Nie, Zheng Kuang, Yongqin Shu, Haifeng Yu, Sixun
AuthorAffiliation	3 Department of Respiratory and Critical Care Diseases, The Fifth Medical Center of PLA General Hospital , Beijing , China 1 Department of Neurosurgery, The General Hospital of Western Theater Command , Chengdu , China 2 Department of Anatomy and Histology and Embryology, Regeneration Key Lab of Sichuan Province, Chengdu Medical College , Chengdu , China
AuthorAffiliation_xml	– name: 3 Department of Respiratory and Critical Care Diseases, The Fifth Medical Center of PLA General Hospital , Beijing , China – name: 2 Department of Anatomy and Histology and Embryology, Regeneration Key Lab of Sichuan Province, Chengdu Medical College , Chengdu , China – name: 1 Department of Neurosurgery, The General Hospital of Western Theater Command , Chengdu , China
Author_xml	– sequence: 1 givenname: Tao surname: Yang fullname: Yang, Tao – sequence: 2 givenname: Zheng surname: Nie fullname: Nie, Zheng – sequence: 3 givenname: Haifeng surname: Shu fullname: Shu, Haifeng – sequence: 4 givenname: Yongqin surname: Kuang fullname: Kuang, Yongqin – sequence: 5 givenname: Xin surname: Chen fullname: Chen, Xin – sequence: 6 givenname: Jingmin surname: Cheng fullname: Cheng, Jingmin – sequence: 7 givenname: Sixun surname: Yu fullname: Yu, Sixun – sequence: 8 givenname: Huiying surname: Liu fullname: Liu, Huiying
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32351365$$D View this record in MEDLINE/PubMed
BookMark	eNp1kc1LHTEUxYNY_Gr3rmSgGzfvNR-TTLIRqtZWEFuKXYdMcqN5zEueyYzgf9_4nhUVukq4Offk3PvbR9sxRUDokOA5Y1J98dHCMKeY4jnGWNIttEeEoDNOMN1-dd9F-6UsMBZUtHIH7TLKOGGC7yF2cwfN7zRAk3xzen590aTYXMOUzdD8GkwZgw3jYxNicw6rDKWEFD-iD94MBT49nwfoz8W3m7Mfs6uf3y_Pvl7NLOdinLHeKux6AN55Dxyocb3qCQenuMGeGlLLne37jredcEpa5YAYT5UE4rFjB-hy4-uSWehVDkuTH3UyQa8LKd9qk2vAAbQkhEiQgrTEtBbaXprWqM51FiT2WFavk43XauqX4CzEsY74xvTtSwx3-jY96I50reC8Ghw_G-R0P0EZ9TKUuv3BREhT0ZQpUf8XlFTp53fSRZpyrKuqKqkUU9W0qo5eJ3qJ8o9NFeCNwOZUSgb_IiFYP-HXa_z6Cb9e468t4l1LpWfGyqzOFIb_N_4FRW60gQ
CitedBy_id	crossref_primary_10_3390_jpm13040652 crossref_primary_10_3389_fphar_2021_666790 crossref_primary_10_3390_molecules28186666 crossref_primary_10_3390_ph17121674 crossref_primary_10_1016_j_lfs_2021_119904 crossref_primary_10_1016_j_braen_2025_100005 crossref_primary_10_1080_1028415X_2022_2110188 crossref_primary_10_1007_s12035_021_02507_6 crossref_primary_10_1007_s12035_025_05238_0 crossref_primary_10_3390_cells11040748 crossref_primary_10_3390_ijerph191912901 crossref_primary_10_3390_ijms21197088 crossref_primary_10_3390_ijerph17196942 crossref_primary_10_1002_cpt_2487 crossref_primary_10_3390_ijms25158526 crossref_primary_10_1016_j_phrs_2022_106281 crossref_primary_10_1016_j_jep_2025_119960 crossref_primary_10_3390_ijms221810051 crossref_primary_10_1007_s11064_025_04419_6 crossref_primary_10_1016_j_ejphar_2024_176525 crossref_primary_10_1155_2021_8819380 crossref_primary_10_1093_bioadv_vbaf196 crossref_primary_10_3390_ijms252413480 crossref_primary_10_1002_jcb_30558 crossref_primary_10_3389_fpsyt_2022_996733 crossref_primary_10_1016_j_npep_2025_102538 crossref_primary_10_1007_s11033_025_10248_1 crossref_primary_10_3389_fphar_2025_1621762 crossref_primary_10_1016_j_bbi_2021_02_007 crossref_primary_10_2147_JMDH_S322355 crossref_primary_10_1016_j_arr_2025_102780 crossref_primary_10_1016_j_pmip_2024_100139 crossref_primary_10_1016_j_genhosppsych_2024_02_011 crossref_primary_10_1007_s11064_023_04064_x crossref_primary_10_1016_j_chemosphere_2024_141165 crossref_primary_10_1016_j_intimp_2023_110520 crossref_primary_10_3390_ijms25063281 crossref_primary_10_1038_s41386_024_01853_y crossref_primary_10_3390_biom11020252 crossref_primary_10_1016_j_jep_2024_118124 crossref_primary_10_1038_s41386_023_01626_z crossref_primary_10_1038_s41398_022_02166_8 crossref_primary_10_3390_nu15183960 crossref_primary_10_3389_fcvm_2022_906483 crossref_primary_10_3389_fnut_2024_1298281 crossref_primary_10_3390_genes14112037 crossref_primary_10_3390_ijms252313098 crossref_primary_10_1007_s11101_025_10125_6 crossref_primary_10_1097_01_JAA_0000921252_57819_4b crossref_primary_10_1016_j_jand_2021_07_016 crossref_primary_10_1016_j_pnpbp_2025_111457 crossref_primary_10_1016_j_ejphar_2023_176161 crossref_primary_10_1016_j_jad_2025_02_038 crossref_primary_10_3390_ijms231911729 crossref_primary_10_3390_diagnostics13091585 crossref_primary_10_3390_healthcare13030269 crossref_primary_10_1016_j_jafr_2025_102272 crossref_primary_10_1016_j_pbb_2023_173523 crossref_primary_10_3390_pharmaceutics16111397 crossref_primary_10_31083_j_jin2303051 crossref_primary_10_7759_cureus_43533 crossref_primary_10_3390_jcm14041337 crossref_primary_10_1134_S1819712423010154 crossref_primary_10_1016_j_jep_2024_118906 crossref_primary_10_1097_JCP_0000000000001396 crossref_primary_10_1016_j_phrs_2024_107566 crossref_primary_10_1007_s13530_024_00229_5 crossref_primary_10_1038_s42003_025_07975_3 crossref_primary_10_3390_cells10102628 crossref_primary_10_3390_ph15030284 crossref_primary_10_1016_j_neuropharm_2024_109870 crossref_primary_10_1167_tvst_14_7_5 crossref_primary_10_1111_jne_13500 crossref_primary_10_3390_metabo12040358 crossref_primary_10_1039_D5FO02698A crossref_primary_10_1080_02648725_2022_2164417 crossref_primary_10_1007_s44337_024_00114_7 crossref_primary_10_3389_fnins_2024_1434309 crossref_primary_10_1016_j_jff_2021_104432 crossref_primary_10_1016_j_neubiorev_2022_104800 crossref_primary_10_2174_1574885517666220817122840 crossref_primary_10_1016_j_bbi_2022_08_005 crossref_primary_10_1155_adpp_6965826 crossref_primary_10_3390_cells13100790 crossref_primary_10_3389_fphar_2022_913210 crossref_primary_10_1038_s41598_021_83348_0 crossref_primary_10_1111_jnc_70062 crossref_primary_10_1016_j_pbb_2023_173706 crossref_primary_10_1016_j_brainresbull_2025_111338 crossref_primary_10_1016_j_lfs_2023_121803 crossref_primary_10_3389_fnbeh_2022_850623 crossref_primary_10_1111_jne_13179 crossref_primary_10_1007_s11418_023_01763_1 crossref_primary_10_1007_s11064_025_04447_2 crossref_primary_10_3389_fnmol_2022_844295 crossref_primary_10_1038_s41598_022_22179_z crossref_primary_10_1177_1559325821998486 crossref_primary_10_1186_s12991_023_00448_z crossref_primary_10_2147_PTT_S535900 crossref_primary_10_1080_17460441_2023_2214361 crossref_primary_10_1002_brb3_2581 crossref_primary_10_1016_j_lfs_2023_122222 crossref_primary_10_3390_ijtm4010010 crossref_primary_10_3389_fpsyt_2022_991753 crossref_primary_10_3390_brainsci13020163 crossref_primary_10_3390_antiox14050585 crossref_primary_10_1016_j_bmcl_2020_127714 crossref_primary_10_1007_s11356_025_36607_w crossref_primary_10_1177_15459683231177595 crossref_primary_10_1016_j_dscb_2025_100189 crossref_primary_10_3389_fnmol_2022_1028223 crossref_primary_10_3390_ijms22147611 crossref_primary_10_1111_cns_14180 crossref_primary_10_1016_j_pharmthera_2024_108641 crossref_primary_10_3389_fphar_2025_1585290 crossref_primary_10_3390_ph17080997 crossref_primary_10_3390_nu15061382 crossref_primary_10_1002_jdn_10380 crossref_primary_10_3390_pharmaceutics15082081 crossref_primary_10_3390_ijms221910256 crossref_primary_10_1016_j_bbr_2023_114509 crossref_primary_10_1016_j_psj_2024_104636 crossref_primary_10_1136_bjsports_2024_108562 crossref_primary_10_1007_s10578_021_01246_y crossref_primary_10_1007_s11011_023_01302_7 crossref_primary_10_1016_j_biopha_2025_118582 crossref_primary_10_1016_j_jep_2025_120423 crossref_primary_10_3390_brainsci15030252 crossref_primary_10_1016_j_neuint_2023_105571 crossref_primary_10_3390_brainsci15030254 crossref_primary_10_3390_brainsci14111133 crossref_primary_10_3390_cells10092492 crossref_primary_10_3389_fnins_2024_1353131 crossref_primary_10_1097_MJT_0000000000001724 crossref_primary_10_1007_s12272_021_01337_3 crossref_primary_10_1097_MJT_0000000000001722 crossref_primary_10_1016_j_neuint_2024_105738 crossref_primary_10_1016_j_jchemneu_2022_102186 crossref_primary_10_1016_j_jconrel_2023_01_061 crossref_primary_10_4103_jrms_jrms_823_21 crossref_primary_10_1186_s43556_024_00205_y crossref_primary_10_1002_brb3_2990 crossref_primary_10_3389_fpsyg_2022_814633 crossref_primary_10_1016_j_phrs_2024_107090 crossref_primary_10_1124_jpet_123_001824 crossref_primary_10_7554_eLife_102222 crossref_primary_10_3390_ijms25158256 crossref_primary_10_1016_j_wneu_2023_02_101 crossref_primary_10_7554_eLife_102222_3 crossref_primary_10_1111_pcn_13664 crossref_primary_10_1002_jbt_23311 crossref_primary_10_1007_s40263_021_00877_y crossref_primary_10_1016_j_neuro_2022_03_011 crossref_primary_10_3390_life14030306 crossref_primary_10_1155_2021_9639131 crossref_primary_10_3390_genes13040646 crossref_primary_10_3390_ijms26178280 crossref_primary_10_3389_fnins_2021_698633 crossref_primary_10_1016_j_lfs_2021_119765 crossref_primary_10_1016_j_jneuroim_2025_578744 crossref_primary_10_3389_fnins_2022_847572 crossref_primary_10_1007_s12035_022_02966_5 crossref_primary_10_1096_fj_202201348R crossref_primary_10_3390_ijms252111840 crossref_primary_10_1017_neu_2022_20 crossref_primary_10_1016_j_jpsychores_2023_111470 crossref_primary_10_1017_S0007114523002301 crossref_primary_10_3390_life13101967 crossref_primary_10_3390_ijms231810896 crossref_primary_10_1016_j_smrv_2022_101738 crossref_primary_10_1111_cns_70167 crossref_primary_10_1016_j_ibneur_2022_10_004 crossref_primary_10_3390_brainsci12121667 crossref_primary_10_3389_fnbeh_2021_626906 crossref_primary_10_3390_ijms22083872 crossref_primary_10_3233_JAD_230801 crossref_primary_10_3389_fnmol_2022_918852 crossref_primary_10_1111_jnc_16270 crossref_primary_10_1016_j_exger_2024_112539 crossref_primary_10_1007_s11064_022_03779_7 crossref_primary_10_3390_ijms26157317 crossref_primary_10_1186_s40337_022_00630_w crossref_primary_10_3390_ph14090894 crossref_primary_10_1093_imammb_dqac016 crossref_primary_10_1080_1028415X_2022_2110664 crossref_primary_10_3389_fpsyt_2025_1526791 crossref_primary_10_1016_j_arr_2024_102211 crossref_primary_10_1016_j_brainresbull_2022_07_009 crossref_primary_10_3389_fpsyt_2022_1040217 crossref_primary_10_1016_j_neubiorev_2023_105113 crossref_primary_10_1016_j_jep_2023_116254 crossref_primary_10_3389_fpsyt_2024_1372650 crossref_primary_10_1016_j_biopha_2025_118373 crossref_primary_10_1016_j_brainres_2022_147845 crossref_primary_10_1186_s13287_023_03264_0 crossref_primary_10_1016_j_jep_2024_119224 crossref_primary_10_1021_acs_jmedchem_5c01750 crossref_primary_10_1038_s41398_023_02533_z crossref_primary_10_2174_1381612829666230103161824 crossref_primary_10_1038_s41598_021_04020_1 crossref_primary_10_1002_brb3_2949 crossref_primary_10_1016_j_brainres_2025_149643 crossref_primary_10_1016_j_tice_2025_102911 crossref_primary_10_1016_j_pbb_2022_173497 crossref_primary_10_1134_S0362119723700664 crossref_primary_10_1016_j_drudis_2022_103467 crossref_primary_10_3389_fnhum_2025_1609654 crossref_primary_10_1039_D0FO03340E crossref_primary_10_1016_j_bbii_2023_100037 crossref_primary_10_1177_0004867421998795 crossref_primary_10_3390_ijms232314876 crossref_primary_10_3390_ijms232314995 crossref_primary_10_3390_antiox12020470 crossref_primary_10_3390_medicines10080045 crossref_primary_10_1007_s11332_025_01353_6 crossref_primary_10_4103_NRR_NRR_D_24_01019 crossref_primary_10_1016_j_pbb_2023_173556 crossref_primary_10_1016_j_clnu_2025_06_005 crossref_primary_10_1073_pnas_2305775120 crossref_primary_10_1016_j_mjafi_2020_09_014 crossref_primary_10_1186_s12964_024_01691_x crossref_primary_10_1186_s41983_021_00337_w crossref_primary_10_1016_j_heliyon_2022_e10774 crossref_primary_10_3389_fpsyt_2022_933704 crossref_primary_10_1016_j_chembiol_2023_10_009 crossref_primary_10_1016_j_ctcp_2025_102016 crossref_primary_10_1007_s00210_024_03777_2 crossref_primary_10_1186_s12868_024_00844_5 crossref_primary_10_3389_fnins_2024_1527842 crossref_primary_10_1016_j_jphotobiol_2024_112998 crossref_primary_10_1016_j_psychres_2022_114857 crossref_primary_10_1007_s12035_020_02145_4 crossref_primary_10_1016_j_lfs_2023_121546 crossref_primary_10_3389_fneur_2021_657004 crossref_primary_10_1016_j_semcdb_2022_09_007 crossref_primary_10_3390_ijms23105856 crossref_primary_10_3390_ph14080821 crossref_primary_10_1016_j_ejphar_2022_175385 crossref_primary_10_1016_j_psyneuen_2025_107615 crossref_primary_10_1007_s12035_022_02889_1 crossref_primary_10_1016_j_euroneuro_2022_09_006 crossref_primary_10_14336_AD_2024_0239 crossref_primary_10_3390_foods14122054 crossref_primary_10_1111_bcpt_13595 crossref_primary_10_3390_biologics5010007 crossref_primary_10_3389_fpsyt_2021_727117
Cites_doi	10.31887/DCNS.2014.16.1/rduman 10.1016/j.pnpbp.2019.109686 10.1016/0896-6273(92)90067-n 10.1176/appi.ajp.2012.12020248 10.1016/j.psychres.2013.12.009 10.1016/j.pharmthera.2009.06.001 10.1038/nn.2505 10.1002/jnr.21139 10.1016/j.biopsych.2011.06.006 10.3109/15622971003611319 10.1186/1756-6606-2-27 10.1126/science.1083328 10.1038/nn1659 10.1007/978-3-642-45106-5_17 10.1038/srep21222 10.1016/s0165-1781(02)00005-7 10.1523/JNEUROSCI.4998-12.2013 10.1007/978-3-642-45106-5_6 10.1097/jgp.0b013e318050c9d5 10.1002/dneu.20774 10.1073/pnas.0709102105 10.1073/pnas.1422336112 10.1016/j.tins.2012.12.010 10.1038/sj.npp.1300320 10.1016/j.nbd.2016.07.010 10.1523/jneurosci.16-07-02365.1996 10.1126/science.1129663 10.1016/s0959-4388(00)00092-1 10.1016/j.neuron.2015.04.007 10.3389/fnmol.2014.00094 10.1523/jneurosci.3741-04.2005 10.1016/s0006-3223(99)00230-9 10.1136/ebn.2011.100200 10.1523/jneurosci.22-05-01532.2002 10.1016/j.expneurol.2004.11.016 10.1186/s40345-019-0161-0 10.1523/jneurosci.15-11-07539.1995 10.1007/978-3-642-45106-5_2 10.1038/mp.2009.67 10.1007/978-3-642-45106-5_5 10.1038/mp.2012.187 10.1016/j.neuroscience.2005.12.058 10.1016/s0896-6273(02)00653-0 10.1096/fj.02-0143fje 10.1016/j.pnpbp.2008.10.005 10.1016/s0006-3223(01)01083-6 10.1038/npp.2008.208 10.1038/ncomms3490 10.1038/nn1969 10.1523/jneurosci.4297-06.2006 10.1016/j.jad.2015.09.021 10.1016/j.neuron.2014.03.021 10.1038/mp.2013.105 10.1002/dneu.20758 10.3389/fnbeh.2014.00143 10.1016/s0896-6273(00)80853-3 10.1016/j.ejphar.2015.12.029 10.1126/science.1100135 10.1016/j.neuroscience.2006.08.069 10.1177/1073858402238511 10.1038/nn.3237 10.1073/pnas.0337481100 10.1016/j.neuropharm.2015.10.034 10.1016/j.celrep.2014.10.016 10.31887/DCNS.2008.10.4/gracagni 10.1038/nature10130 10.1146/annurev.ne.19.030196.001445 10.1523/jneurosci.5123-04.2005 10.1126/science.1150516 10.1016/s0006-3223(99)00177-8 10.1016/j.biopsych.2011.09.030 10.1155/2017/6871089 10.1016/0166-2236(91)90097-e 10.1016/j.biopsych.2006.02.013 10.1126/science.1065057 10.1038/nn1971 10.1038/nn.2799 10.1523/jneurosci.5048-11.2012 10.1038/npp.2010.8 10.1074/jbc.m700607200 10.1073/pnas.0402141101 10.1016/s0893-133x(01)00358-x 10.1073/pnas.92.19.8856 10.1016/s0896-6273(02)00942-x 10.1016/s0028-3908(98)00035-5 10.1093/cercor/bhi104 10.1017/s1461145712000016 10.1523/jneurosci.4037-06.2007 10.1126/science.1222939 10.3390/ijms17030381 10.1073/pnas.0803702105 10.1371/journal.pone.0211241 10.1128/MCB.00150-13 10.1016/j.biopsych.2008.05.005 10.1124/pr.111.005108 10.1002/msj.20043 10.1523/JNEUROSCI.0119-10.2010 10.1038/npp.2010.114 10.1016/j.biopsych.2012.05.031 10.1098/rstb.2006.1894 10.1073/pnas.40.10.1014 10.1073/pnas.1015950108 10.1523/jneurosci.23-01-00349.2003 10.1016/j.neuropharm.2013.06.024 10.1016/j.biopsych.2006.03.082 10.1016/j.pharmthera.2011.05.007 10.1016/bs.vh.2016.10.004 10.1016/j.tins.2010.01.001 10.4088/JCP.08m04659 10.1016/j.jpsychires.2006.06.011 10.1016/s0092-8674(03)00035-7 10.1038/nn1510 10.1001/archpsyc.63.8.856 10.1083/jcb.201201038 10.1155/2013/318596 10.2165/11530010-000000000-00000 10.4088/JCP.11096su1c.01 10.1002/j.1460-2075.1982.tb01207.x 10.1111/j.1460-9568.2010.07486.x 10.1038/mp.2011.113 10.1017/S1461145713001119 10.1523/jneurosci.6034-11.2012 10.1523/jneurosci.1405-10.2010 10.1016/j.ygeno.2007.05.004 10.1002/dev.21297 10.1016/j.biopsych.2006.03.021 10.1126/science.1152864 10.1371/journal.pone.0094666 10.1016/j.biopsych.2007.09.019 10.1007/978-3-642-45106-5_1 10.1523/JNEUROSCI.22-08-03251.2002 10.1371/journal.pone.0115280 10.1038/nature07455 10.1111/j.1460-9568.2010.07488.x 10.1007/s12035-015-9569-4 10.1016/0014-5793(95)01520-5 10.1038/mp.2010.98 10.1016/j.neuropharm.2013.05.029 10.1101/lm.67804 10.1155/2012/631965 10.1038/nrn3379 10.1038/nature02319 10.1126/scisignal.2002060 10.1016/j.euroneuro.2013.12.010 10.1083/jcb.201504092 10.1152/jn.00797.2007
ContentType	Journal Article
Copyright	Copyright © 2020 Yang, Nie, Shu, Kuang, Chen, Cheng, Yu and Liu. 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2020 Yang, Nie, Shu, Kuang, Chen, Cheng, Yu and Liu. 2020 Yang, Nie, Shu, Kuang, Chen, Cheng, Yu and Liu
Copyright_xml	– notice: Copyright © 2020 Yang, Nie, Shu, Kuang, Chen, Cheng, Yu and Liu. – notice: 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Copyright © 2020 Yang, Nie, Shu, Kuang, Chen, Cheng, Yu and Liu. 2020 Yang, Nie, Shu, Kuang, Chen, Cheng, Yu and Liu
DBID	AAYXX CITATION NPM 3V. 7XB 88I 8FE 8FH 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO GNUQQ HCIFZ LK8 M2P M7P PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA
DOI	10.3389/fncel.2020.00082
DatabaseName	CrossRef PubMed ProQuest Central (Corporate) ProQuest Central (purchase pre-March 2016) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Journals ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Database ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central ProQuest Central Student ProQuest SciTech Premium Collection Biological Sciences Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ - Directory of Open Access Journals
DatabaseTitle	CrossRef PubMed Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Central (New) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition Biological Science Database ProQuest SciTech Collection ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Publicly Available Content Database MEDLINE - Academic PubMed
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1662-5102
ExternalDocumentID	oai_doaj_org_article_81118e86141a4ce4b8a4a97d7ce80f08 PMC7174655 32351365 10_3389_fncel_2020_00082
Genre	Journal Article
GrantInformation_xml	– fundername: National Natural Science Foundation of China grantid: 81300986, 81371430, 81271395
GroupedDBID	--- 29H 2WC 53G 5GY 5VS 88I 8FE 8FH 9T4 AAFWJ AAYXX ABUWG ACGFO ACGFS ADBBV ADRAZ AEGXH AENEX AFFHD AFKRA AFPKN AIAGR ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ CCPQU CITATION CS3 DIK DWQXO E3Z EMOBN F5P GNUQQ GROUPED_DOAJ GX1 HCIFZ HYE KQ8 LK8 M2P M48 M7P M~E O5R O5S OK1 OVT PGMZT PHGZM PHGZT PIMPY PQGLB PQQKQ PROAC RNS RPM TR2 ACXDI C1A IAO IEA IHR IHW IPNFZ ISR NPM RIG 3V. 7XB 8FK PKEHL PQEST PQUKI PRINS Q9U 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c556t-3bc90dbee57ffe5e2adb9b15ed95a0f2a1ffe7cbb75476d98c9de1af298e1f0d3
IEDL.DBID	M2P
ISICitedReferencesCount	273
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000531351800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1662-5102
IngestDate	Fri Oct 03 12:53:35 EDT 2025 Tue Nov 04 02:00:48 EST 2025 Fri Sep 05 06:43:16 EDT 2025 Fri Jul 25 11:50:14 EDT 2025 Thu Jan 02 22:59:24 EST 2025 Sat Nov 29 05:35:54 EST 2025 Tue Nov 18 21:50:58 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	neurogenesis depression BDNF neural plasticity neurotrophic factors
Language	English
License	Copyright © 2020 Yang, Nie, Shu, Kuang, Chen, Cheng, Yu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c556t-3bc90dbee57ffe5e2adb9b15ed95a0f2a1ffe7cbb75476d98c9de1af298e1f0d3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Specialty section: This article was submitted to Cellular Neurophysiology, a section of the journal Frontiers in Cellular Neuroscience Reviewed by: Ranji Cui, Second Affiliated Hospital of Jilin University, China; Bingjin Li, Jilin University, China; Wenbo Luo, Liaoning Normal University, China Edited by: Bin Song, McLean Hospital, United States These authors share first authorship
OpenAccessLink	https://www.proquest.com/docview/2389939717?pq-origsite=%requestingapplication%
PMID	32351365
PQID	2389939717
PQPubID	4424410
ParticipantIDs	doaj_primary_oai_doaj_org_article_81118e86141a4ce4b8a4a97d7ce80f08 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7174655 proquest_miscellaneous_2396861621 proquest_journals_2389939717 pubmed_primary_32351365 crossref_primary_10_3389_fncel_2020_00082 crossref_citationtrail_10_3389_fncel_2020_00082
PublicationCentury	2000
PublicationDate	2020-04-15
PublicationDateYYYYMMDD	2020-04-15
PublicationDate_xml	– month: 04 year: 2020 text: 2020-04-15 day: 15
PublicationDecade	2020
PublicationPlace	Switzerland
PublicationPlace_xml	– name: Switzerland – name: Lausanne
PublicationTitle	Frontiers in cellular neuroscience
PublicationTitleAlternate	Front Cell Neurosci
PublicationYear	2020
Publisher	Frontiers Research Foundation Frontiers Media S.A
Publisher_xml	– name: Frontiers Research Foundation – name: Frontiers Media S.A
References	Molteni (B96); 34 Verpelli (B141) 2010; 30 Deinhardt (B35) 2014; 220 Amaral (B6) 2007; 98 Radley (B115); 26 Saarelainen (B119) 2003; 23 Molendijk (B95) 2014; 19 Briz (B20) 2015; 210 Tanaka (B132) 2008; 319 Kaplan (B62) 2000; 10 Alcaide (B3) 2019; 7 Sairanen (B122) 2007; 144 Koshimizu (B69) 2009; 2 Castrén (B27); 24 Hempstead (B56) 2014; 220 Lee (B78) 2001; 294 Kuhn (B72) 2014; 9 Cohen (B32) 1954; 40 Erickson (B49) 2011; 108 Chan (B28) 2016; 189 Ninan (B104) 2010; 30 Duman (B42) 1999; 46 Bosch (B18) 2014; 82 Colla (B34) 2007; 41 Pang (B108) 2004; 306 Anastasia (B7) 2013; 4 Pruunsild (B113) 2007; 90 Frodl (B52) 2010; 35 Radley (B116); 16 Castrén (B25) 2017; 97 Thompson (B136) 2012; 15 Shirayama (B130) 2002; 22 Chen (B29) 2001; 50 Molteni (B97); 124 Lindholm (B80) 2014; 8 Luoni (B84) 2016; 53 Martinowich (B87) 2007; 10 Jeanneteau (B59) 2008; 105 Björkholm (B16) 2016; 102 Kuipers (B73) 2016; 6 Leal (B77) 2017; 104 Maya Vetencourt (B88) 2008; 320 Taliaz (B131) 2010; 15 Ji (B61) 2010; 13 Sen (B127) 2008; 75 Dwivedi (B45) 2006; 139 Hennings (B57) 2019; 95 Hirschfeld (B58) 2012; 73 Tzanoulinou (B140) 2014; 9 Laje (B75) 2012; 72 Banasr (B11) 2004; 29 Nibuya (B102) 1996; 16 Zagrebelsky (B145) 2014; 76 Chen (B30) 2011; 14 Tripp (B137) 2012; 169 Caldeira (B22) 2007; 282 Rex (B118) 2007; 27 Haile (B55) 2014; 17 Kasai (B64) 2010; 33 Autry (B10) 2012; 64 Castrén (B26); 70 MacQueen (B86) 2003; 100 Aid (B2) 2007; 85 Lai (B74) 2012; 15 Bergami (B13) 2008; 105 Dranovsky (B38) 2006; 59 Schmidt (B125) 2010; 35 Tyler (B139) 2002; 8 Sheline (B129) 2011; 70 Barde (B12) 1982; 1 Calabrese (B21) 2011; 132 Panja (B109) 2014; 76 Reichardt (B117) 2006; 361 Chen (B31) 2006; 314 Minichiello (B92) 1999; 24 Minichiello (B91) 2002; 36 Lambert (B76) 2013; 33 Sen (B128) 2008; 64 Autry (B9) 2011; 475 Nibuya (B101) 1995; 15 Karege (B63) 2002; 109 Berry (B15) 2015; 57 Cohen-Cory (B33) 2010; 70 Taylor (B133) 2007; 15 Duric (B44) 2013; 16 Nykjaer (B107) 2004; 427 Woo (B142) 2005; 8 Castrén (B23) 2014; 220 Dieni (B37) 2012; 196 Monteggia (B98) 2004; 101 Kaster (B65) 2016; 771 Tsankova (B138) 2006; 9 Castrén (B24) 2013; 36 Hagihara (B54) 2013; 2013 Bocchio-Chiavetto (B17) 2010; 11 Monteggia (B99) 2007; 61 Duman (B39) 2014; 16 Luoni (B83) 2014; 24 Nestler (B100) 2002; 34 Park (B111) 2013; 14 Niitsu (B103) 2014; 215 Guilloux (B53) 2012; 17 Nosyreva (B106) 2013; 33 Alonso (B5) 2004; 11 Feyissa (B50) 2009; 33 Ying (B143) 2002; 22 Mizui (B93) 2015; 112 Egan (B47) 2003; 112 Zarate (B146) 2006; 63 Katoh-Semba (B66) 2002; 16 Liu (B82) 2017; 2017 Korte (B67) 1995; 92 Korte (B68) 1998; 37 Bothwell (B19) 2014; 220 Molendijk (B94) 2011; 16 Lewin (B79) 1996; 19 Liu (B81) 2012; 71 Machado-Vieira (B85) 2009; 70 Panja (B110) 2014; 9 Racagni (B114) 2008; 10 Scharfman (B124) 2005; 192 Fortin (B51) 2012; 32 Aldoghachi (B4) 2019; 14 Duman (B40) 2012; 338 Adachi (B1) 2008; 63 Thoenen (B135) 1991; 14 Berman (B14) 2000; 47 Anderson (B8) 2011; 33 Yu (B144) 2012; 32 Krishnan (B71) 2008; 455 Teng (B134) 2005; 25 Duman (B43) 2001; 25 Eisenberg (B48) 2013; 18 Jeon (B60) 2016; 17 Nosyreva (B105) 2014; 7 Maya Vetencourt (B89) 2011; 33 Kraemer (B70) 2014; 220 Santarelli (B123) 2003; 301 Sahay (B120) 2007; 10 Maya-Vetencourt (B90) 2012; 2012 Deinhardt (B36) 2011; 4 Seidah (B126) 1996; 379 Duman (B41) 2006; 59 Patterson (B112) 1992; 9 Sairanen (B121) 2005; 25 Edelmann (B46) 2015; 86
References_xml	– volume: 16 start-page: 11 year: 2014 ident: B39 article-title: Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections publication-title: Dialogues Clin. Neurosci. doi: 10.31887/DCNS.2014.16.1/rduman – volume: 95 start-page: 109686 year: 2019 ident: B57 article-title: Polymorphisms in the BDNF and BDNFOS genes are associated with hypothalamus-pituitary axis regulation in major depression publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry doi: 10.1016/j.pnpbp.2019.109686 – volume: 9 start-page: 1081 year: 1992 ident: B112 article-title: Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs publication-title: Neuron doi: 10.1016/0896-6273(92)90067-n – volume: 169 start-page: 1194 year: 2012 ident: B137 article-title: Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2012.12020248 – volume: 215 start-page: 268 year: 2014 ident: B103 article-title: A positive correlation between serum levels of mature brain-derived neurotrophic factor and negative symptoms in schizophrenia publication-title: Psychiatry Res. doi: 10.1016/j.psychres.2013.12.009 – volume: 124 start-page: 74 ident: B97 article-title: Antipsychotic drug actions on gene modulation and signaling mechanisms publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2009.06.001 – volume: 13 start-page: 302 year: 2010 ident: B61 article-title: Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons publication-title: Nat. Neurosci. doi: 10.1038/nn.2505 – volume: 85 start-page: 525 year: 2007 ident: B2 article-title: Mouse and rat BDNF gene structure and expression revisited publication-title: J. Neurosci. Res. doi: 10.1002/jnr.21139 – volume: 70 start-page: 308 year: 2011 ident: B129 article-title: Depression and the hippocampus: cause or effect? publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2011.06.006 – volume: 11 start-page: 763 year: 2010 ident: B17 article-title: Serum and plasma BDNF levels in major depression: a replication study and meta-analyses publication-title: World J. Biol. Psychiatry doi: 10.3109/15622971003611319 – volume: 2 start-page: 27 year: 2009 ident: B69 article-title: Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival publication-title: Mol. Brain doi: 10.1186/1756-6606-2-27 – volume: 301 start-page: 805 year: 2003 ident: B123 article-title: Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants publication-title: Science doi: 10.1126/science.1083328 – volume: 9 start-page: 519 year: 2006 ident: B138 article-title: Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action publication-title: Nat. Neurosci. doi: 10.1038/nn1659 – volume: 220 start-page: 461 year: 2014 ident: B23 article-title: Neurotrophins and psychiatric disorders publication-title: Handb. Exp. Pharmacol. doi: 10.1007/978-3-642-45106-5_17 – volume: 6 start-page: 21222 year: 2016 ident: B73 article-title: BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis publication-title: Sci. Rep. doi: 10.1038/srep21222 – volume: 109 start-page: 143 year: 2002 ident: B63 article-title: Decreased serum brain-derived neurotrophic factor levels in major depressed patients publication-title: Psychiatry Res. doi: 10.1016/s0165-1781(02)00005-7 – volume: 33 start-page: 6990 year: 2013 ident: B106 article-title: Acute suppression of spontaneous neurotransmission drives synaptic potentiation publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4998-12.2013 – volume: 220 start-page: 121 year: 2014 ident: B70 article-title: The biological functions and signaling mechanisms of the p75 neurotrophin receptor publication-title: Handb. Exp. Pharmacol. doi: 10.1007/978-3-642-45106-5_6 – volume: 15 start-page: 850 year: 2007 ident: B133 article-title: Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression publication-title: Am. J. Geriatr. Psychiatry doi: 10.1097/jgp.0b013e318050c9d5 – volume: 70 start-page: 271 year: 2010 ident: B33 article-title: Brain-derived neurotrophic factor and the development of structural neuronal connectivity publication-title: Dev. Neurobiol. doi: 10.1002/dneu.20774 – volume: 105 start-page: 4862 year: 2008 ident: B59 article-title: Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.0709102105 – volume: 112 start-page: E3067 year: 2015 ident: B93 article-title: BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.1422336112 – volume: 36 start-page: 259 year: 2013 ident: B24 article-title: Neuronal plasticity and antidepressant actions publication-title: Trends Neurosci. doi: 10.1016/j.tins.2012.12.010 – volume: 29 start-page: 450 year: 2004 ident: B11 article-title: Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300320 – volume: 97 start-page: 119 year: 2017 ident: B25 article-title: Brain-derived neurotrophic factor in mood disorders and antidepressant treatments publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2016.07.010 – volume: 16 start-page: 2365 year: 1996 ident: B102 article-title: Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus publication-title: J. Neurosci. doi: 10.1523/jneurosci.16-07-02365.1996 – volume: 314 start-page: 140 year: 2006 ident: B31 article-title: Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior publication-title: Science doi: 10.1126/science.1129663 – volume: 10 start-page: 381 year: 2000 ident: B62 article-title: Neurotrophin signal transduction in the nervous system publication-title: Curr. Opin. Neurobiol. doi: 10.1016/s0959-4388(00)00092-1 – volume: 86 start-page: 1041 year: 2015 ident: B46 article-title: Theta burst firing recruits BDNF release and signaling in postsynaptic CA1 neurons in spike-timing-dependent LTP publication-title: Neuron doi: 10.1016/j.neuron.2015.04.007 – volume: 7 start-page: 94 year: 2014 ident: B105 article-title: Age dependence of the rapid antidepressant and synaptic effects of acute NMDA receptor blockade publication-title: Front. Mol. Neurosci. doi: 10.3389/fnmol.2014.00094 – volume: 25 start-page: 1089 year: 2005 ident: B121 article-title: Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation and survival in the adult dentate gyrus publication-title: J. Neurosci. doi: 10.1523/jneurosci.3741-04.2005 – volume: 47 start-page: 351 year: 2000 ident: B14 article-title: Antidepressant effects of ketamine in depressed patients publication-title: Biol. Psychiatry doi: 10.1016/s0006-3223(99)00230-9 – volume: 15 start-page: 35 year: 2012 ident: B136 article-title: Motivational interviewing improves patients’ mood and reduces mortality 12 months poststroke publication-title: Evid. Based Nurs. doi: 10.1136/ebn.2011.100200 – volume: 22 start-page: 1532 year: 2002 ident: B143 article-title: Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis publication-title: J. Neurosci. doi: 10.1523/jneurosci.22-05-01532.2002 – volume: 192 start-page: 348 year: 2005 ident: B124 article-title: Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2004.11.016 – volume: 7 start-page: 24 year: 2019 ident: B3 article-title: Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients publication-title: Int. J. Bipolar Disord. doi: 10.1186/s40345-019-0161-0 – volume: 15 start-page: 7539 year: 1995 ident: B101 article-title: Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments publication-title: J. Neurosci. doi: 10.1523/jneurosci.15-11-07539.1995 – volume: 220 start-page: 17 year: 2014 ident: B56 article-title: Deciphering proneurotrophin actions publication-title: Handb. Exp. Pharmacol. doi: 10.1007/978-3-642-45106-5_2 – volume: 15 start-page: 80 year: 2010 ident: B131 article-title: Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis publication-title: Mol. Psychiatry doi: 10.1038/mp.2009.67 – volume: 220 start-page: 103 year: 2014 ident: B35 article-title: Trk receptors publication-title: Handb. Exp. Pharmacol. doi: 10.1007/978-3-642-45106-5_5 – volume: 18 start-page: 713 year: 2013 ident: B48 article-title: Brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia publication-title: Mol. Psychiatry doi: 10.1038/mp.2012.187 – volume: 139 start-page: 1017 year: 2006 ident: B45 article-title: Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone publication-title: Neuroscience doi: 10.1016/j.neuroscience.2005.12.058 – volume: 34 start-page: 13 year: 2002 ident: B100 article-title: Neurobiology of depression publication-title: Neuron doi: 10.1016/s0896-6273(02)00653-0 – volume: 16 start-page: 1328 year: 2002 ident: B66 article-title: Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus publication-title: FASEB J. doi: 10.1096/fj.02-0143fje – volume: 33 start-page: 70 year: 2009 ident: B50 article-title: Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry doi: 10.1016/j.pnpbp.2008.10.005 – volume: 50 start-page: 260 year: 2001 ident: B29 article-title: Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication publication-title: Biol. Psychiatry doi: 10.1016/s0006-3223(01)01083-6 – volume: 34 start-page: 1523 ident: B96 article-title: Acute stress responsiveness of the neurotrophin BDNF in the rat hippocampus is modulated by chronic treatment with the antidepressant duloxetine publication-title: Neuropsychopharmacology doi: 10.1038/npp.2008.208 – volume: 4 start-page: 2490 year: 2013 ident: B7 article-title: Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction publication-title: Nat. Commun. doi: 10.1038/ncomms3490 – volume: 10 start-page: 1110 year: 2007 ident: B120 article-title: Adult hippocampal neurogenesis in depression publication-title: Nat. Neurosci. doi: 10.1038/nn1969 – volume: 26 start-page: 12967 ident: B115 article-title: Regional differentiation of the medial prefrontal cortex in regulating adaptive responses to acute emotional stress publication-title: J. Neurosci. doi: 10.1523/jneurosci.4297-06.2006 – volume: 189 start-page: 199 year: 2016 ident: B28 article-title: Hippocampal volume in vulnerability and resilience to depression publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2015.09.021 – volume: 82 start-page: 444 year: 2014 ident: B18 article-title: Structural and molecular remodeling of dendritic spine substructures during long-term potentiation publication-title: Neuron doi: 10.1016/j.neuron.2014.03.021 – volume: 19 start-page: 791 year: 2014 ident: B95 article-title: Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484) publication-title: Mol. Psychiatry doi: 10.1038/mp.2013.105 – volume: 70 start-page: 289 ident: B26 article-title: The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity publication-title: Dev. Neurobiol. doi: 10.1002/dneu.20758 – volume: 8 start-page: 143 year: 2014 ident: B80 article-title: Mice with altered BDNF signaling as models for mood disorders and antidepressant effects publication-title: Front. Behav. Neurosci. doi: 10.3389/fnbeh.2014.00143 – volume: 24 start-page: 401 year: 1999 ident: B92 article-title: Essential role for TrkB receptors in hippocampus-mediated learning publication-title: Neuron doi: 10.1016/s0896-6273(00)80853-3 – volume: 771 start-page: 236 year: 2016 ident: B65 article-title: Novel approaches for the management of depressive disorders publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2015.12.029 – volume: 306 start-page: 487 year: 2004 ident: B108 article-title: Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity publication-title: Science doi: 10.1126/science.1100135 – volume: 144 start-page: 368 year: 2007 ident: B122 article-title: Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat publication-title: Neuroscience doi: 10.1016/j.neuroscience.2006.08.069 – volume: 8 start-page: 524 year: 2002 ident: B139 article-title: The role of neurotrophins in neurotransmitter release publication-title: Neuroscientist doi: 10.1177/1073858402238511 – volume: 15 start-page: 1506 year: 2012 ident: B74 article-title: TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory publication-title: Nat. Neurosci. doi: 10.1038/nn.3237 – volume: 100 start-page: 1387 year: 2003 ident: B86 article-title: Course of illness, hippocampal function, and hippocampal volume in major depression publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.0337481100 – volume: 102 start-page: 72 year: 2016 ident: B16 article-title: BDNF–a key transducer of antidepressant effects publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2015.10.034 – volume: 9 start-page: 1430 year: 2014 ident: B110 article-title: Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK publication-title: Cell Rep. doi: 10.1016/j.celrep.2014.10.016 – volume: 10 start-page: 385 year: 2008 ident: B114 article-title: Cellular and molecular mechanisms in the long-term action of antidepressants publication-title: Dialogues Clin. Neurosci. doi: 10.31887/DCNS.2008.10.4/gracagni – volume: 475 start-page: 91 year: 2011 ident: B9 article-title: NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses publication-title: Nature doi: 10.1038/nature10130 – volume: 19 start-page: 289 year: 1996 ident: B79 article-title: Physiology of the neurotrophins publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.ne.19.030196.001445 – volume: 25 start-page: 5455 year: 2005 ident: B134 article-title: ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin publication-title: J. Neurosci. doi: 10.1523/jneurosci.5123-04.2005 – volume: 320 start-page: 385 year: 2008 ident: B88 article-title: The antidepressant fluoxetine restores plasticity in the adult visual cortex publication-title: Science doi: 10.1126/science.1150516 – volume: 46 start-page: 1181 year: 1999 ident: B42 article-title: Neural plasticity to stress and antidepressant treatment publication-title: Biol. Psychiatry doi: 10.1016/s0006-3223(99)00177-8 – volume: 71 start-page: 996 year: 2012 ident: B81 article-title: Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2011.09.030 – volume: 2017 start-page: 6871089 year: 2017 ident: B82 article-title: The role of neural plasticity in depression: from hippocampus to prefrontal cortex publication-title: Neural Plast. doi: 10.1155/2017/6871089 – volume: 14 start-page: 165 year: 1991 ident: B135 article-title: The changing scene of neurotrophic factors publication-title: Trends Neurosci. doi: 10.1016/0166-2236(91)90097-e – volume: 59 start-page: 1116 year: 2006 ident: B41 article-title: A neurotrophic model for stress-related mood disorders publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2006.02.013 – volume: 294 start-page: 1945 year: 2001 ident: B78 article-title: Regulation of cell survival by secreted proneurotrophins publication-title: Science doi: 10.1126/science.1065057 – volume: 10 start-page: 1089 year: 2007 ident: B87 article-title: New insights into BDNF function in depression and anxiety publication-title: Nat. Neurosci. doi: 10.1038/nn1971 – volume: 14 start-page: 587 year: 2011 ident: B30 article-title: Structural basis for the role of inhibition in facilitating adult brain plasticity publication-title: Nat. Neurosci. doi: 10.1038/nn.2799 – volume: 32 start-page: 4092 year: 2012 ident: B144 article-title: Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants publication-title: J. Neurosci. doi: 10.1523/jneurosci.5048-11.2012 – volume: 35 start-page: 1383 year: 2010 ident: B52 article-title: Childhood stress, serotonin transporter gene and brain structures in major depression publication-title: Neuropsychopharmacology doi: 10.1038/npp.2010.8 – volume: 282 start-page: 12619 year: 2007 ident: B22 article-title: Brain-derived neurotrophic factor regulates the expression and synaptic delivery of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons publication-title: J. Biol. Chem. doi: 10.1074/jbc.m700607200 – volume: 101 start-page: 10827 year: 2004 ident: B98 article-title: Essential role of brain-derived neurotrophic factor in adult hippocampal function publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.0402141101 – volume: 25 start-page: 836 year: 2001 ident: B43 article-title: Regulation of adult neurogenesis by antidepressant treatment publication-title: Neuropsychopharmacology doi: 10.1016/s0893-133x(01)00358-x – volume: 92 start-page: 8856 year: 1995 ident: B67 article-title: Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.92.19.8856 – volume: 36 start-page: 121 year: 2002 ident: B91 article-title: Mechanism of TrkB-mediated hippocampal long-term potentiation publication-title: Neuron doi: 10.1016/s0896-6273(02)00942-x – volume: 37 start-page: 553 year: 1998 ident: B68 article-title: A role for BDNF in the late-phase of hippocampal long-term potentiation publication-title: Neuropharmacology doi: 10.1016/s0028-3908(98)00035-5 – volume: 16 start-page: 313 ident: B116 article-title: Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex publication-title: Cereb. Cortex doi: 10.1093/cercor/bhi104 – volume: 16 start-page: 69 year: 2013 ident: B44 article-title: Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects publication-title: Int. J. Neuropsychopharmacol. doi: 10.1017/s1461145712000016 – volume: 27 start-page: 3017 year: 2007 ident: B118 article-title: Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus publication-title: J. Neurosci. doi: 10.1523/jneurosci.4037-06.2007 – volume: 338 start-page: 68 year: 2012 ident: B40 article-title: Synaptic dysfunction in depression: potential therapeutic targets publication-title: Science doi: 10.1126/science.1222939 – volume: 17 start-page: 381 year: 2016 ident: B60 article-title: Molecular neurobiology and promising new treatment in depression publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms17030381 – volume: 105 start-page: 15570 year: 2008 ident: B13 article-title: Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.0803702105 – volume: 14 start-page: e0211241 year: 2019 ident: B4 article-title: Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients publication-title: PLoS One doi: 10.1371/journal.pone.0211241 – volume: 33 start-page: 3700 year: 2013 ident: B76 article-title: Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00150-13 – volume: 64 start-page: 527 year: 2008 ident: B128 article-title: Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2008.05.005 – volume: 64 start-page: 238 year: 2012 ident: B10 article-title: Brain-derived neurotrophic factor and neuropsychiatric disorders publication-title: Pharmacol. Rev. doi: 10.1124/pr.111.005108 – volume: 75 start-page: 204 year: 2008 ident: B127 article-title: Major depression: emerging therapeutics publication-title: Mt. Sinai J. Med. doi: 10.1002/msj.20043 – volume: 30 start-page: 5830 year: 2010 ident: B141 article-title: Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0119-10.2010 – volume: 35 start-page: 2378 year: 2010 ident: B125 article-title: Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models publication-title: Neuropsychopharmacology doi: 10.1038/npp.2010.114 – volume: 72 start-page: e27 year: 2012 ident: B75 article-title: Brain-derived neurotrophic factor Val66Met polymorphism and antidepressant efficacy of ketamine in depressed patients publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2012.05.031 – volume: 361 start-page: 1545 year: 2006 ident: B117 article-title: Neurotrophin-regulated signalling pathways publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. doi: 10.1098/rstb.2006.1894 – volume: 40 start-page: 1014 year: 1954 ident: B32 article-title: A nerve growth-stimulating factor isolated from sarcom as 37 and 180 publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.40.10.1014 – volume: 108 start-page: 3017 year: 2011 ident: B49 article-title: Exercise training increases size of hippocampus and improves memory publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.1015950108 – volume: 23 start-page: 349 year: 2003 ident: B119 article-title: Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects publication-title: J. Neurosci. doi: 10.1523/jneurosci.23-01-00349.2003 – volume: 76 start-page: 664 year: 2014 ident: B109 article-title: BDNF mechanisms in late LTP formation: a synthesis and breakdown publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2013.06.024 – volume: 59 start-page: 1136 year: 2006 ident: B38 article-title: Hippocampal neurogenesis: regulation by stress and antidepressants publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2006.03.082 – volume: 132 start-page: 39 year: 2011 ident: B21 article-title: Antistress properties of antidepressant drugs and their clinical implications publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2011.05.007 – volume: 104 start-page: 153 year: 2017 ident: B77 article-title: BDNF and hippocampal synaptic plasticity publication-title: Vitam. Horm. doi: 10.1016/bs.vh.2016.10.004 – volume: 33 start-page: 121 year: 2010 ident: B64 article-title: Structural dynamics of dendritic spines in memory and cognition publication-title: Trends Neurosci. doi: 10.1016/j.tins.2010.01.001 – volume: 70 start-page: 1662 year: 2009 ident: B85 article-title: Brain-derived neurotrophic factor and initial antidepressant response to an N-methyl-D-aspartate antagonist publication-title: J. Clin. Psychiatry doi: 10.4088/JCP.08m04659 – volume: 41 start-page: 553 year: 2007 ident: B34 article-title: Hippocampal volume reduction and HPA-system activity in major depression publication-title: J. Psychiatr. Res. doi: 10.1016/j.jpsychires.2006.06.011 – volume: 112 start-page: 257 year: 2003 ident: B47 article-title: The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function publication-title: Cell doi: 10.1016/s0092-8674(03)00035-7 – volume: 8 start-page: 1069 year: 2005 ident: B142 article-title: Activation of p75NTR by proBDNF facilitates hippocampal long-term depression publication-title: Nat. Neurosci. doi: 10.1038/nn1510 – volume: 63 start-page: 856 year: 2006 ident: B146 article-title: A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.63.8.856 – volume: 196 start-page: 775 year: 2012 ident: B37 article-title: BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons publication-title: J. Cell Biol. doi: 10.1083/jcb.201201038 – volume: 2013 start-page: 318596 year: 2013 ident: B54 article-title: Immature dentate gyrus: an endophenotype of neuropsychiatric disorders publication-title: Neural Plast. doi: 10.1155/2013/318596 – volume: 24 start-page: 1 ident: B27 article-title: Role of brain-derived neurotrophic factor in the aetiology of depression: implications for pharmacological treatment publication-title: CNS Drugs doi: 10.2165/11530010-000000000-00000 – volume: 73 start-page: 5 year: 2012 ident: B58 article-title: The epidemiology of depression and the evolution of treatment publication-title: J. Clin. Psychiatry doi: 10.4088/JCP.11096su1c.01 – volume: 1 start-page: 549 year: 1982 ident: B12 article-title: Purification of a new neurotrophic factor from mammalian brain publication-title: EMBO J. doi: 10.1002/j.1460-2075.1982.tb01207.x – volume: 33 start-page: 175 year: 2011 ident: B8 article-title: Associative learning increases adult neurogenesis during a critical period publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2010.07486.x – volume: 17 start-page: 1130 year: 2012 ident: B53 article-title: Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression publication-title: Mol. Psychiatry doi: 10.1038/mp.2011.113 – volume: 17 start-page: 331 year: 2014 ident: B55 article-title: Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression publication-title: Int. J. Neuropsychopharmacol. doi: 10.1017/S1461145713001119 – volume: 32 start-page: 8127 year: 2012 ident: B51 article-title: Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors publication-title: J. Neurosci. doi: 10.1523/jneurosci.6034-11.2012 – volume: 30 start-page: 8866 year: 2010 ident: B104 article-title: The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus publication-title: J. Neurosci. doi: 10.1523/jneurosci.1405-10.2010 – volume: 90 start-page: 397 year: 2007 ident: B113 article-title: Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters publication-title: Genomics doi: 10.1016/j.ygeno.2007.05.004 – volume: 57 start-page: 365 year: 2015 ident: B15 article-title: Decreased Bdnf expression and reduced social behavior in periadolescent rats following prenatal stress publication-title: Dev. Psychobiol. doi: 10.1002/dev.21297 – volume: 61 start-page: 187 year: 2007 ident: B99 article-title: Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2006.03.021 – volume: 319 start-page: 1683 year: 2008 ident: B132 article-title: Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines publication-title: Science doi: 10.1126/science.1152864 – volume: 9 start-page: e94666 year: 2014 ident: B140 article-title: Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the Amygdala publication-title: PLoS One doi: 10.1371/journal.pone.0094666 – volume: 63 start-page: 642 year: 2008 ident: B1 article-title: Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2007.09.019 – volume: 220 start-page: 3 year: 2014 ident: B19 article-title: NGF, BDNF, NT3, and NT4 publication-title: Handb. Exp. Pharmacol. doi: 10.1007/978-3-642-45106-5_1 – volume: 22 start-page: 3251 year: 2002 ident: B130 article-title: Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.22-08-03251.2002 – volume: 9 start-page: e115280 year: 2014 ident: B72 article-title: Fear extinction as a model for synaptic plasticity in major depressive disorder publication-title: PLoS One doi: 10.1371/journal.pone.0115280 – volume: 455 start-page: 894 year: 2008 ident: B71 article-title: The molecular neurobiology of depression publication-title: Nature doi: 10.1038/nature07455 – volume: 33 start-page: 49 year: 2011 ident: B89 article-title: Serotonin triggers a transient epigenetic mechanism that reinstates adult visual cortex plasticity in rats publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2010.07488.x – volume: 53 start-page: 7037 year: 2016 ident: B84 article-title: Sex-specific effects of prenatal stress on Bdnf expression in response to an acute challenge in rats: a role for Gadd45β publication-title: Mol. Neurobiol. doi: 10.1007/s12035-015-9569-4 – volume: 379 start-page: 247 year: 1996 ident: B126 article-title: Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases publication-title: FEBS Lett. doi: 10.1016/0014-5793(95)01520-5 – volume: 16 start-page: 1088 year: 2011 ident: B94 article-title: Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment publication-title: Mol. Psychiatry doi: 10.1038/mp.2010.98 – volume: 76 start-page: 628 year: 2014 ident: B145 article-title: Form follows function: BDNF and its involvement in sculpting the function and structure of synapses publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2013.05.029 – volume: 11 start-page: 172 year: 2004 ident: B5 article-title: ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons publication-title: Learn. Mem. doi: 10.1101/lm.67804 – volume: 2012 start-page: 631965 year: 2012 ident: B90 article-title: Visual cortex plasticity: a complex interplay of genetic and environmental influences publication-title: Neural Plast. doi: 10.1155/2012/631965 – volume: 14 start-page: 7 year: 2013 ident: B111 article-title: Neurotrophin regulation of neural circuit development and function publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3379 – volume: 427 start-page: 843 year: 2004 ident: B107 article-title: Sortilin is essential for proNGF-induced neuronal cell death publication-title: Nature doi: 10.1038/nature02319 – volume: 4 start-page: ra82 year: 2011 ident: B36 article-title: Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac publication-title: Sci. Signal. doi: 10.1126/scisignal.2002060 – volume: 24 start-page: 986 year: 2014 ident: B83 article-title: Delayed BDNF alterations in the prefrontal cortex of rats exposed to prenatal stress: preventive effect of lurasidone treatment during adolescence publication-title: Eur. Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2013.12.010 – volume: 210 start-page: 1225 year: 2015 ident: B20 article-title: A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release publication-title: J. Cell Biol. doi: 10.1083/jcb.201504092 – volume: 98 start-page: 2476 year: 2007 ident: B6 article-title: BDNF induces calcium elevations associated with IBDNF, a nonselective cationic current mediated by TRPC channels publication-title: J. Neurophysiol. doi: 10.1152/jn.00797.2007
SSID	ssj0062648
Score	2.6358514
SecondaryResourceType	review_article
Snippet	Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes... Recent studies combining pharmacological, behavioral, electrophysiological and molecular approaches indicate that depression results from maladaptive...
SourceID	doaj pubmedcentral proquest pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	82
SubjectTerms	Amygdala Apoptosis BDNF Behavioral plasticity Brain-derived neurotrophic factor Cellular Neuroscience depression Drug therapy Gene expression Hypotheses Intracellular signalling Kinases Ligands Mental depression Neostriatum neural plasticity Neurogenesis Neurons Neurotrophic factors Phosphorylation Plasticity (neural) Prefrontal cortex Proteins Transcription
SummonAdditionalLinks	– databaseName: DOAJ - Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwEB2hCiEuCGiBQItcqZceoo0TO7aPlHbFAVZVBag3yx9jsVKVoHaL1H9fT5JddRGCC1d_JM6bOJ7RvLwBODKVRC9cDksimlI4nUrthSgbHbD1kvtqYLt__6wWC315ac4flPoiTtgoDzwCN9N5M2rU-RThTgQUXjvhjIoqoK7S-Jtvpcw6mBq_wS3xtsakZA7BzCxlACnPUBOPq9L11iE0aPX_ycH8nSf54OCZP4dnk8fIPowrfQGPsHsJT75MOfFdaLKl2UV_haxP7OR0MWd9x0hzI086z74x0aZXd2zZsdM167Xbg2_zs68fP5VTKYQySNmuysYHU0WPKFVKKLF20RvPJUYjXZVqx3OzCt4rKVQbjQ4mInepNhp5qmLzCna6vsM3wHLIl5QyqFOiYCToJKNrNSrRohBOFDBbY2PDpBNO5SqubI4XCE07oGkJTTugWcDxZsbPUSPjL2NPCO7NOFK3Hhqyze1kc_svmxewvzaWnbbcja1JKTB7V1wVcLjpzpuFMiCuw_6Wxpg2X7ateQGvR9tuVtLUjSTOXwFqy-pbS93u6ZY_BkHufE-SoXv7P57tHTwltChhxeU-7Kyub_EAHodfq-XN9fvhLb8Hfv8CDw priority: 102 providerName: Directory of Open Access Journals
Title	The Role of BDNF on Neural Plasticity in Depression
URI	https://www.ncbi.nlm.nih.gov/pubmed/32351365 https://www.proquest.com/docview/2389939717 https://www.proquest.com/docview/2396861621 https://pubmed.ncbi.nlm.nih.gov/PMC7174655 https://doaj.org/article/81118e86141a4ce4b8a4a97d7ce80f08
Volume	14
WOSCitedRecordID	wos000531351800001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1662-5102 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0062648 issn: 1662-5102 databaseCode: DOA dateStart: 20070101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1662-5102 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0062648 issn: 1662-5102 databaseCode: M~E dateStart: 20070101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1662-5102 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0062648 issn: 1662-5102 databaseCode: M7P dateStart: 20071230 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central (subscription) customDbUrl: eissn: 1662-5102 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0062648 issn: 1662-5102 databaseCode: BENPR dateStart: 20071230 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1662-5102 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0062648 issn: 1662-5102 databaseCode: PIMPY dateStart: 20071230 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1662-5102 dateEnd: 20211231 omitProxy: false ssIdentifier: ssj0062648 issn: 1662-5102 databaseCode: M2P dateStart: 20071230 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lj9MwEB6xuwjthfcjsFRB4sIhapzYsX1ClG0FEq2iFaByimxnDJVWyW7bReLCb8eTpoUitBcuPviRjDwz9ozn0wzAS50KtNwEt6RGnXCjfKIs50muHBZWMJt2aPfPH-RspuZzXfYPbqseVrk9E7uDum4dvZEPM0oEFy5PJl9fXCZUNYqiq30JjQM4CpYNI0jXNCu3J3FB6K1NaDI4YnrowzZStCEjNFeqsr2rqMvY_y8z82-05B_Xz-TO_xJ-F273hmf8ZiMp9-AGNvfh1rQPrT-APAhMfNaeY9z6eHQ6m8RtE1PqjrCoDCY2oa_XP-JFE59uwbPNQ_g0GX98-y7pKyokTohineTW6bS2iEJ6jwIzU1ttmcBaC5P6zLDQLZ21UnBZ1Fo5XSMzPtMKmU_r_BEcNm2DTyAOnqOXUqPynnwap7yoTaFQ8gI5NzyC4XZzK9enG6eqF-dVcDuIHVXHjorYUXXsiODVbsXFJtXGNXNHxK_dPEqS3XW0y69Vr3OVCue4QhUMEGa4Q26V4UbLWjpUqU9VBCdbjlW95q6q3-yK4MVuOOgcBVJMg-0VzdFF-GyRsQgeb4RjR0me5YKggxHIPbHZI3V_pFl86_J6h39SNrun15P1DI5pHyiixcQJHK6XV_gcbrrv68VqOYADOVcDOBqNZ-XZoHthGHRKQa3s2p_jMF6-n5ZffgFahhfZ
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VgoAL70egQJDgwCHaxLFj-4AQZaladbtaoYJ6C7YzhpWqpOxuQf1T_EY82WRhEeqtB67xI5ZnPOPJfPkG4IVOBVpuQlhSoU64UT5RlvMkVw4LKzKbtmj3TyM5HqujIz3ZgJ_9vzAEq-xtYmuoq8bRN_IBIyK44Dwz-ebkW0JVoyi72pfQWKrFPp79CCHb_PXeMMj3JWM77w_f7SZdVYHECVEsktw6nVYWUUjvUSAzldU2E1hpYVLPTBYeS2etFFwWlVZOV5gZz7TCzKdVHua9BJc5MYsRVJBNestfEFpsmQoNgZ8e-CA2ym4wQo-liq25vrZCwL-utX-jM_9wdzs3_7eNugU3uot1_HZ5Em7DBtZ34OpBBx24C3k4EPGH5hjjxsfbw_FO3NQxUZOEQZMQQhC6fHEWT-t42IOD63vw8UKWfB8266bGhxCHyNhLqVF5TzGbU15UplAoeYGcGx7BoBdm6To6darqcVyGsIrEX7biL0n8ZSv-CF6tRpwsqUTO6btN-rHqRyTg7YNm9qXsbEqpgp9SqMIFKzPcIbfKcKNlJR2q1Kcqgq1eQ8rOMs3L3-oRwfNVc7AplCgyNTan1EcXYdqCZRE8WCrjaiU5ywVBIyOQa2q6ttT1lnr6teUtD-8ktr5H5y_rGVzbPTwYlaO98f5juE57Qtm7TGzB5mJ2ik_givu-mM5nT9vDF8Pni1biX7yjcwA
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VLaq48H4ECgQJDhyiTRw7tg8IUZYVq7arFQJUTsFOxrBSlZTdLah_jV-HJ4-FRai3HrjGj1j253lkvswAPNWxQMuNd0tK1BE3ykXKch6lqsDMisTGDdv944GcTtXRkZ5twc_-XxiiVfYysRHUZV3QN_Iho0RwXnkmcug6WsRsNH558i2iClIUae3LabQQ2cezH959W76YjPxZP2Ns_Ob967dRV2EgKoTIVlFqCx2XFlFI51AgM6XVNhFYamFix0ziH8vCWim4zEqtCl1iYhzTChMXl6mf9xJse5OcswFszyaHs0-9HsiIO9YGRr0bqIfOHyLFOhhxyWLFNhRhUy_gX0bu31zNP5Tf-Nr_vG3X4Wpncoev2jtyA7awugk7hx2p4Bak_qqE7-pjDGsX7o2m47CuQkpa4gfNvHNBvPPVWTivwlFPG65uw4cLWfIdGFR1hfcg9D6zk1Kjco68uUI5UZpMoeQZcm54AMP-YPOiS7RO9T6Oc-9wERTyBgo5QSFvoBDA8_WIkzbJyDl99wgr636UHrx5UC--5J20yZXXYAqVN70SwwvkVhlutCxlgSp2sQpgt0dL3smsZf4bKgE8WTd7aUMhJFNhfUp9dOanzVgSwN0WmOuVpCwVRJoMQG5AdmOpmy3V_GuT0dy_k_L43T9_WY9hx2M3P5hM9x_AFdoSCuslYhcGq8UpPoTLxffVfLl41N3EED5fNIp_ASKefUk
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Role+of+BDNF+on+Neural+Plasticity+in+Depression&rft.jtitle=Frontiers+in+cellular+neuroscience&rft.au=Yang%2C+Tao&rft.au=Nie%2C+Zheng&rft.au=Shu%2C+Haifeng&rft.au=Kuang%2C+Yongqin&rft.date=2020-04-15&rft.pub=Frontiers+Research+Foundation&rft.eissn=1662-5102&rft_id=info:doi/10.3389%2Ffncel.2020.00082&rft.externalDBID=HAS_PDF_LINK
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1662-5102&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1662-5102&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1662-5102&client=summon