The Role of BDNF on Neural Plasticity in Depression

Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. Meanwhile, functions of the brain-derived neurotr...

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Veröffentlicht in:Frontiers in cellular neuroscience Jg. 14; S. 82
Hauptverfasser: Yang, Tao, Nie, Zheng, Shu, Haifeng, Kuang, Yongqin, Chen, Xin, Cheng, Jingmin, Yu, Sixun, Liu, Huiying
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland Frontiers Research Foundation 15.04.2020
Frontiers Media S.A
Schlagworte:
Amygdala
Apoptosis
BDNF
Behavioral plasticity
Brain-derived neurotrophic factor
Cellular Neuroscience
depression
Drug therapy
Gene expression
Hypotheses
Intracellular signalling
Kinases
Ligands
Mental depression
Neostriatum
neural plasticity
Neurogenesis
Neurons
Neurotrophic factors
Phosphorylation
Plasticity (neural)
Prefrontal cortex
Proteins
Transcription
neurogenesis
depression
BDNF
neural plasticity
neurotrophic factors
ISSN:1662-5102, 1662-5102
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. Meanwhile, functions of the brain-derived neurotrophic factor (BDNF) and the other neurotrophins in the pathogenesis of depression are well known. The maladaptive neuroplastic in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of neurotrophic factors signaling has great potential in therapy for depression. This review highlights the relevance of neurotrophic factors mediated neural plasticity and pathophysiology of depression. These studies reviewed here may suggest new possible targets for antidepressant drugs such as neurotrophins, their receptors, and relevant signaling pathways, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophic factors in the brain.
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Specialty section: This article was submitted to Cellular Neurophysiology, a section of the journal Frontiers in Cellular Neuroscience
Reviewed by: Ranji Cui, Second Affiliated Hospital of Jilin University, China; Bingjin Li, Jilin University, China; Wenbo Luo, Liaoning Normal University, China
Edited by: Bin Song, McLean Hospital, United States
These authors share first authorship
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2020.00082