Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis

Sepsis is characterized by profound changes in systemic and cellular metabolism that disrupt normal metabolic homeostasis. These metabolic changes can serve as biomarkers for disease severity. Lactate, a metabolite of anaerobic metabolism, is the most widely used ICU biomarker and it is incorporated...

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Bibliographic Details
Published in:Clinics in chest medicine Vol. 37; no. 2; p. 321
Main Authors: Englert, Joshua A, Rogers, Angela J
Format: Journal Article
Language:English
Published: United States 01.06.2016
Subjects:
Biomarkers - blood
Humans
Metabolomics - methods
Nutritional Support - methods
Sepsis - metabolism
Sepsis - therapy
Metabolomics
Sepsis
Biomarker
Nutrition
Metabolism
ICU outcomes
ISSN:1557-8216, 1557-8216
Online Access:Get more information
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Summary:Sepsis is characterized by profound changes in systemic and cellular metabolism that disrupt normal metabolic homeostasis. These metabolic changes can serve as biomarkers for disease severity. Lactate, a metabolite of anaerobic metabolism, is the most widely used ICU biomarker and it is incorporated into multiple management algorithms. Technological advances now make broader metabolic profiling possible, with early studies identifying metabolic changes associated with sepsis mortality. Finally, given the marked changes in metabolism in sepsis and the association of worse prognosis in patients with severe metabolic derangements, we summarize the seminal trials conducted to optimize nutrition in the ICU.
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ISSN:1557-8216
1557-8216
DOI:10.1016/j.ccm.2016.01.011