Inflammation: The Common Pathway of Stress-Related Diseases

While modernization has dramatically increased lifespan, it has also witnessed that the nature of stress has changed dramatically. Chronic stress result failures of homeostasis thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, w...

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Veröffentlicht in:Frontiers in human neuroscience Jg. 11; S. 1 - 11
Hauptverfasser: Liu, Yun-Zi, Wang, Yun-Xia, Jiang, Chun-Lei
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland Frontiers Research Foundation 20.06.2017
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Abstract While modernization has dramatically increased lifespan, it has also witnessed that the nature of stress has changed dramatically. Chronic stress result failures of homeostasis thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%-90% of human diseases is related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable. Chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood. Here we discuss the role of inflammation in stress-induced diseases and suggest a common pathway for stress-related diseases that is based on chronic mild inflammation. This framework highlights the fundamental impact of inflammation mechanisms and provides a new perspective on the prevention and treatment of stress-related diseases.
AbstractList While modernization has dramatically increased lifespan, it has also witnessed that the nature of stress has changed dramatically. Chronic stress result failures of homeostasis thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%-90% of human diseases is related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable. Chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood. Here we discuss the role of inflammation in stress-induced diseases and suggest a common pathway for stress-related diseases that is based on chronic mild inflammation. This framework highlights the fundamental impact of inflammation mechanisms and provides a new perspective on the prevention and treatment of stress-related diseases.
While modernization has dramatically increased lifespan, it has also witnessed the nature of stress has changed dramatically. Chronic stress result failures of homeostasis and thus lead to various diseases such as atherosclerosis, nonalcoholic fatty liver (NAFLD) and depression. However, while 75%-90% of human diseases related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable. Chronic inflammation is an essential component of chronic diseases. Additionally, Accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood. Here we discuss the role of inflammation in stress-induced diseases and suggest a common pathway for stress-related diseases that is based on chronic mild inflammation. This framework highlights the fundamental impact of inflammation mechanisms and provides a new perspective on the prevention and treatment of stress-related diseases.
While modernization has dramatically increased lifespan, it has also witnessed that the nature of stress has changed dramatically. Chronic stress result failures of homeostasis thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%-90% of human diseases is related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable. Chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood. Here we discuss the role of inflammation in stress-induced diseases and suggest a common pathway for stress-related diseases that is based on chronic mild inflammation. This framework highlights the fundamental impact of inflammation mechanisms and provides a new perspective on the prevention and treatment of stress-related diseases.While modernization has dramatically increased lifespan, it has also witnessed that the nature of stress has changed dramatically. Chronic stress result failures of homeostasis thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%-90% of human diseases is related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable. Chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood. Here we discuss the role of inflammation in stress-induced diseases and suggest a common pathway for stress-related diseases that is based on chronic mild inflammation. This framework highlights the fundamental impact of inflammation mechanisms and provides a new perspective on the prevention and treatment of stress-related diseases.
Author Wang, Yun-Xia
Jiang, Chun-Lei
Liu, Yun-Zi
AuthorAffiliation Laboratory of Stress Medicine, Faculty of Psychology and Mental Health, Second Military Medical University Shanghai, China
AuthorAffiliation_xml – name: Laboratory of Stress Medicine, Faculty of Psychology and Mental Health, Second Military Medical University Shanghai, China
Author_xml – sequence: 1
  givenname: Yun-Zi
  surname: Liu
  fullname: Liu, Yun-Zi
– sequence: 2
  givenname: Yun-Xia
  surname: Wang
  fullname: Wang, Yun-Xia
– sequence: 3
  givenname: Chun-Lei
  surname: Jiang
  fullname: Jiang, Chun-Lei
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28676747$$D View this record in MEDLINE/PubMed
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Keywords cardiovascular disease
stress-related disease
neurodegenerative disease
neuroimmunomodulation
inflammation
depression
metabolic disease
neurotransmitter
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Edited by: Dieter J. Meyerhoff, University of California, San Francisco, United States
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Snippet While modernization has dramatically increased lifespan, it has also witnessed that the nature of stress has changed dramatically. Chronic stress result...
While modernization has dramatically increased lifespan, it has also witnessed the nature of stress has changed dramatically. Chronic stress result failures of...
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SubjectTerms Arteriosclerosis
Atherosclerosis
Cancer
cardiovascular disease
Chronic illnesses
Cytokines
Diabetes
Disease
Fatty liver
Homeostasis
Hypertension
Immune system
Inflammation
Kinases
Life span
metabolic disease
Metabolic disorders
neuroimmunomodulation
Neuropeptides
Neuroscience
neurotransmitter
Physiology
Proteins
Psychosis
Stress
stress-related disease
Tumor necrosis factor-TNF
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Title Inflammation: The Common Pathway of Stress-Related Diseases
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