Inflammation: The Common Pathway of Stress-Related Diseases

While modernization has dramatically increased lifespan, it has also witnessed that the nature of stress has changed dramatically. Chronic stress result failures of homeostasis thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, w...

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Published in:Frontiers in human neuroscience Vol. 11; pp. 1 - 11
Main Authors: Liu, Yun-Zi, Wang, Yun-Xia, Jiang, Chun-Lei
Format: Journal Article
Language:English
Published: Switzerland Frontiers Research Foundation 20.06.2017
Frontiers Media S.A
Subjects:
Arteriosclerosis
Atherosclerosis
Cancer
cardiovascular disease
Chronic illnesses
Cytokines
Diabetes
Disease
Fatty liver
Homeostasis
Hypertension
Immune system
Inflammation
Kinases
Life span
metabolic disease
Metabolic disorders
neuroimmunomodulation
Neuropeptides
Neuroscience
neurotransmitter
Physiology
Proteins
Psychosis
Stress
stress-related disease
Tumor necrosis factor-TNF
cardiovascular disease
stress-related disease
neurodegenerative disease
neuroimmunomodulation
inflammation
depression
metabolic disease
neurotransmitter
ISSN:1662-5161
Online Access:Get full text
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Summary:While modernization has dramatically increased lifespan, it has also witnessed that the nature of stress has changed dramatically. Chronic stress result failures of homeostasis thus lead to various diseases such as atherosclerosis, non-alcoholic fatty liver disease (NAFLD) and depression. However, while 75%-90% of human diseases is related to the activation of stress system, the common pathways between stress exposure and pathophysiological processes underlying disease is still debatable. Chronic inflammation is an essential component of chronic diseases. Additionally, accumulating evidence suggested that excessive inflammation plays critical roles in the pathophysiology of the stress-related diseases, yet the basis for this connection is not fully understood. Here we discuss the role of inflammation in stress-induced diseases and suggest a common pathway for stress-related diseases that is based on chronic mild inflammation. This framework highlights the fundamental impact of inflammation mechanisms and provides a new perspective on the prevention and treatment of stress-related diseases.
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Edited by: Dieter J. Meyerhoff, University of California, San Francisco, United States
Reviewed by: Masaaki Murakami, Hokkaido University, Japan; Leonardo Roever, Federal University of Uberlandia, Brazil; Hector A. Cabrera-Fuentes, Justus Liebig Universität Gießen, Germany
ISSN:1662-5161
DOI:10.3389/fnhum.2017.00316