Methylation Pathways and SARS-CoV-2 Lung Infiltration and Cell Membrane-Virus Fusion Are Both Subject to Epigenetics

The recent pandemic SARS-CoV-2 outbreak affects all kinds of individuals worldwide. The health, social, and economic impacts of the pandemic are dramatic, and vaccines or specific treatment options are not yet available. The only approaches that we currently have available to stop the epidemic are t...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Frontiers in cellular and infection microbiology Ročník 10; s. 290
Hlavný autor: Pruimboom, Leo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Media SA 26.05.2020
Frontiers Media S.A
Predmet:
Aging
Angiotensin-Converting Enzyme 2
Betacoronavirus - genetics
Betacoronavirus - physiology
Cell Fusion
Cell membranes
Cellular and Infection Microbiology
Contact tracing
Coronavirus Infections - drug therapy
Coronavirus Infections - virology
COVID-19
COVID-19 Drug Treatment
Disease Susceptibility
DNA Methylation
Epidemics
Epigenesis, Genetic
Epigenetics
Female
Gene Silencing
Humans
Hygiene
Lung - virology
Male
Membrane fusion
methylation
Pandemics
Peptidyl-Dipeptidase A - genetics
Peptidyl-Dipeptidase A - metabolism
Pneumonia, Viral - drug therapy
Pneumonia, Viral - virology
Receptors, Coronavirus
Receptors, Virus - genetics
Receptors, Virus - metabolism
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
syncytium
Virus Internalization
Viruses
COVID-19
ACE2
SARS-CoV-2
syncytium
cell fusion
methylation
fatality
epigenetics
ISSN:2235-2988, 2235-2988
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:The recent pandemic SARS-CoV-2 outbreak affects all kinds of individuals worldwide. The health, social, and economic impacts of the pandemic are dramatic, and vaccines or specific treatment options are not yet available. The only approaches that we currently have available to stop the epidemic are those of classical epidemic control, such as case isolation, contact tracing and quarantine, physical distancing, and hygiene measures. It is therefore essential to find further preventive measures and possible interventions that can slow down the number of infected individuals and decrease the severity of disease when affected by SARS-CoV-2. It seems that epigenetic mechanisms are an important part of the pathophysiology and illness severity of COVID-19. These mechanisms have been identified in SARS-CoV-2 but also in other viral infections. If and when these mechanisms are confirmed, then epigenetic interventions influencing DNA methylation could be indicated as primary and/or secondary preventive options.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
Reviewed by: Teneema Kuriakose, St. Jude Children's Research Hospital, United States; Jawed Iqbal, Jamia Millia Islamia, India
This article was submitted to Virus and Host, a section of the journal Frontiers in Cellular and Infection Microbiology
Edited by: Slobodan Paessler, The University of Texas Medical Branch at Galveston, United States
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2020.00290