Depressive symptoms, thyroid hormone and autoimmunity in a population-based cohort from Sardinia

To evaluate the association between depressive symptoms and thyroid autoimmunity, and the effect of thyroid hormone on the risk of depression. We included 3138 individuals from SardiNIA project, none of whom was taking thyroid medication and antidepressants. Thyrotropin (TSH), free thyroxine (FT4),...

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Veröffentlicht in:Journal of affective disorders Jg. 191; S. 82 - 87
Hauptverfasser: Delitala, Alessandro P, Terracciano, Antonio, Fiorillo, Edoardo, Orrù, Valeria, Schlessinger, David, Cucca, Francesco
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.02.2016
Schlagworte:
Adult
Autoantibodies - blood
Autoantigens - immunology
Autoimmunity
Center for Epidemiologic Studies Depression Scale
Cross-Sectional Studies
Depression
Depression - immunology
Depressive symptoms
Female
Free thyroxine
Humans
Iodide Peroxidase - immunology
Iron-Binding Proteins - immunology
Italy
Male
Middle Aged
Odds Ratio
Psychiatry
Risk
Thyroid Function Tests
Thyroid Gland - metabolism
Thyroid Gland - physiopathology
Thyroid hormone
Thyroid Hormones - immunology
Thyrotropin - immunology
Thyroxine - immunology
Italy
Depression
Thyroid hormone
Depressive symptoms
Free thyroxine
Center for Epidemiologic Studies Depression Scale
ISSN:0165-0327, 1573-2517
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Beschreibung
Zusammenfassung:To evaluate the association between depressive symptoms and thyroid autoimmunity, and the effect of thyroid hormone on the risk of depression. We included 3138 individuals from SardiNIA project, none of whom was taking thyroid medication and antidepressants. Thyrotropin (TSH), free thyroxine (FT4), and antibodies against thyroperoxidase (TPOAb) were measured in all the sample. Depressive symptoms were assessed with Center for Epidemiologic Studies Depression Scale (CES-D). We found no association between TPOAb and depressive symptoms and no linear association between TSH or FT4 levels and depressive symptoms. However, individuals in the lowest and highest FT4 quintiles showed a higher CES-D score compared to individuals in the middle quintile. In addition, participants in the lowest and highest FT4 quintiles had an increased risk of CES-D≥16 with odds ratios of 1.44 (95% CI=1.09–1.89) and 1.33 (95% CI=1.01−1.77), respectively. Cross-sectional design of the study. A U-shaped relation was found between FT4 and depressive symptoms: compared to average FT4 values, both high and low thyroid function was associated with more depressive symptoms. Further studies are necessary to determine the exact cause-effect relation of this association. •Mood disorders are not related to antibodies against thyroid.•Free thyroxine has a “U-shaped” relation with depressive symptoms.•Free thyroxine is related to depressed mood also in euthyroid subjects.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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These authors contributed equally to this work
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2015.11.019