Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

Ageing is the biggest risk factor for cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated in age‐related tissue dysfunction. Here, we address the question of how senescence is induced in rarely dividing/post‐mitotic cardiomyocytes and inv...

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Bibliographic Details
Published in:	The EMBO journal Vol. 38; no. 5
Main Authors:	Anderson, Rhys, Lagnado, Anthony, Maggiorani, Damien, Walaszczyk, Anna, Dookun, Emily, Chapman, James, Birch, Jodie, Salmonowicz, Hanna, Ogrodnik, Mikolaj, Jurk, Diana, Proctor, Carole, Correia‐Melo, Clara, Victorelli, Stella, Fielder, Edward, Berlinguer‐Palmini, Rolando, Owens, Andrew, Greaves, Laura C, Kolsky, Kathy L, Parini, Angelo, Douin‐Echinard, Victorine, LeBrasseur, Nathan K, Arthur, Helen M, Tual‐Chalot, Simon, Schafer, Marissa J, Roos, Carolyn M, Miller, Jordan D, Robertson, Neil, Mann, Jelena, Adams, Peter D, Tchkonia, Tamara, Kirkland, James L, Mialet‐Perez, Jeanne, Richardson, Gavin D, Passos, João F
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.03.2019 Springer Nature B.V EMBO Press John Wiley and Sons Inc
Subjects:	Age ageing Aging Animals Cardiomegaly - etiology Cardiomegaly - pathology Cardiomyocytes Cardiovascular diseases Cell division Cellular Biology Cellular Senescence Damage Deoxyribonucleic acid DNA DNA Damage EMBO01 EMBO13 EMBO21 Eutrophication Female Fibrosis Fibrosis - etiology Fibrosis - pathology Humans Hypertrophy INK4a protein Life Sciences Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Mitochondria Mitosis Monoamine Oxidase - physiology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology p16 Protein Pharmacology Phenotype Phenotypes Rats, Sprague-Dawley Reactive oxygen species Regeneration Risk analysis Risk factors RNA - physiology Senescence senolytics Telomerase - physiology Telomere Shortening telomeres Yeast cardiomyocytes senescence senolytics ageing telomeres telomeres Subject Categories Ageing Repair & Recombination DNA Replication Metabolism
ISSN:	0261-4189, 1460-2075, 1460-2075
Online Access:	Get full text
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