Transferred melanoma-specific CD8+ T cells persist, mediate tumor regression, and acquire central memory phenotype

Adoptively transferred tumor-specific T cells offer the potential for non-cross-resistant therapy and long-term immunoprotection. Strategies to enhance in vivo persistence of transferred T cells can lead to improved antitumor efficacy. However, the extrinsic (patient conditioning) and intrinsic (eff...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 12; p. 4592
Main Authors:	Chapuis, Aude G, Thompson, John A, Margolin, Kim A, Rodmyre, Rebecca, Lai, Ivy P, Dowdy, Kaye, Farrar, Erik A, Bhatia, Shailender, Sabath, Daniel E, Cao, Jianhong, Li, Yongqing, Yee, Cassian
Format:	Journal Article
Language:	English
Published:	United States 20.03.2012
Subjects:	Adult Aged Animals Autoimmunity CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Cell Proliferation Female Humans Immunologic Memory Immunotherapy - methods Interleukin-1 - metabolism Male Melanoma - immunology Melanoma - therapy Mice Middle Aged Neoplasms - pathology Neoplasms - therapy Phenotype T-Lymphocytes, Cytotoxic - cytology
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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