Quality control and quality assurance in genotypic data for genome-wide association studies

Genome‐wide scans of nucleotide variation in human subjects are providing an increasing number of replicated associations with complex disease traits. Most of the variants detected have small effects and, collectively, they account for a small fraction of the total genetic variance. Very large sampl...

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Vydané v:	Genetic epidemiology Ročník 34; číslo 6; s. 591 - 602
Hlavní autori:	Laurie, Cathy C., Doheny, Kimberly F., Mirel, Daniel B., Pugh, Elizabeth W., Bierut, Laura J., Bhangale, Tushar, Boehm, Frederick, Caporaso, Neil E., Cornelis, Marilyn C., Edenberg, Howard J., Gabriel, Stacy B., Harris, Emily L., Hu, Frank B., Jacobs, Kevin B., Kraft, Peter, Landi, Maria Teresa, Lumley, Thomas, Manolio, Teri A., McHugh, Caitlin, Painter, Ian, Paschall, Justin, Rice, John P., Rice, Kenneth M., Zheng, Xiuwen, Weir, Bruce S.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.09.2010
Predmet:	Aneuploidy Case-Control Studies chromosome aberration Chromosome Aberrations DNA probes DNA sample quality Female Gene Frequency Genetic variance Genetic Variation Genetics, Population Genome-Wide Association Study - methods Genome-Wide Association Study - standards Genotype Genotypes Genotyping genotyping artifact GWAS Hardy-Weinberg equilibrium Humans Lung Neoplasms - genetics Male Polymorphism, Single Nucleotide Principal components analysis Quality Control Sex Chromosome Aberrations - statistics & numerical data Sex chromosomes Single-nucleotide polymorphism Substance-Related Disorders - genetics
ISSN:	0741-0395, 1098-2272, 1098-2272
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