(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis

An elevated level of plasma LDL (low-density lipoprotein) is an established risk factor for cardiovascular disease. Recently, we reported that the (pro)renin receptor ([P]RR) regulates LDL metabolism in vitro via the LDLR (LDL receptor) and SORT1 (sortilin-1), independently of the renin-angiotensin...

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Bibliographic Details
Published in:	Circulation research Vol. 122; no. 5; p. 730
Main Authors:	Ren, Liwei, Sun, Yuan, Lu, Hong, Ye, Dien, Han, Lijuan, Wang, Na, Daugherty, Alan, Li, Furong, Wang, Miaomiao, Su, Fengting, Tao, Wenjun, Sun, Jie, Zelcer, Noam, Mullick, Adam E, Danser, A H Jan, Jiang, Yizhou, He, Yongcheng, Ruan, Xiongzhong, Lu, Xifeng
Format:	Journal Article
Language:	English
Published:	United States 02.03.2018
Subjects:	Acetyl-CoA Carboxylase - metabolism Adaptor Proteins, Vesicular Transport - metabolism Animals Cells, Cultured Diet, High-Fat - adverse effects Fatty Liver - etiology Fatty Liver - metabolism Gene Silencing Hep G2 Cells Hepatocytes - metabolism Humans Lipid Metabolism Male Mice Mice, Inbred C57BL Obesity - etiology Obesity - metabolism Prorenin Receptor Pyruvate Dehydrogenase Complex - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism hypertriglyceridemia dyslipidemia liver vacuolar H+-ATPase hypercholesterolemia renin–angiotensin system
ISSN:	1524-4571, 1524-4571
Online Access:	Get more information
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