Controlling Visually Guided Behavior by Holographic Recalling of Cortical Ensembles

Neurons in cortical circuits are often coactivated as ensembles, yet it is unclear whether ensembles play a functional role in behavior. Some ensemble neurons have pattern completion properties, triggering the entire ensemble when activated. Using two-photon holographic optogenetics in mouse primary...

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Bibliographic Details
Published in:Cell Vol. 178; no. 2; p. 447
Main Authors: Carrillo-Reid, Luis, Han, Shuting, Yang, Weijian, Akrouh, Alejandro, Yuste, Rafael
Format: Journal Article
Language:English
Published: United States 11.07.2019
Subjects:
Animals
Area Under Curve
Behavior, Animal
Calcium - metabolism
Holography
Image Processing, Computer-Assisted
Male
Mice
Mice, Inbred C57BL
Neurons - metabolism
Optogenetics - methods
Photic Stimulation
Photons
ROC Curve
Visual Cortex - physiology
Pattern Completion
Neuronal ensembles
Learned behavior manipulation
Two-photon optogenetics
Two-photon imaging
ISSN:1097-4172, 1097-4172
Online Access:Get more information
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Summary:Neurons in cortical circuits are often coactivated as ensembles, yet it is unclear whether ensembles play a functional role in behavior. Some ensemble neurons have pattern completion properties, triggering the entire ensemble when activated. Using two-photon holographic optogenetics in mouse primary visual cortex, we tested whether recalling ensembles by activating pattern completion neurons alters behavioral performance in a visual task. Disruption of behaviorally relevant ensembles by activation of non-selective neurons decreased performance, whereas activation of only two pattern completion neurons from behaviorally relevant ensembles improved performance, by reliably recalling the whole ensemble. Also, inappropriate behavioral choices were evoked by the mistaken activation of behaviorally relevant ensembles. Finally, in absence of visual stimuli, optogenetic activation of two pattern completion neurons could trigger behaviorally relevant ensembles and correct behavioral responses. Our results demonstrate a causal role of neuronal ensembles in a visually guided behavior and suggest that ensembles implement internal representations of perceptual states.
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2019.05.045