Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

Multiple signatures of somatic mutations have been identified in cancer genomes. Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common mutational signatures, indicating past activity of the underlying processes, usually in appropriate cancer types. To investigate o...

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Vydáno v:	Cell Ročník 176; číslo 6; s. 1282
Hlavní autoři:	Petljak, Mia, Alexandrov, Ludmil B, Brammeld, Jonathan S, Price, Stacey, Wedge, David C, Grossmann, Sebastian, Dawson, Kevin J, Ju, Young Seok, Iorio, Francesco, Tubio, Jose M C, Koh, Ching Chiek, Georgakopoulos-Soares, Ilias, Rodríguez-Martín, Bernardo, Otlu, Burçak, O'Meara, Sarah, Butler, Adam P, Menzies, Andrew, Bhosle, Shriram G, Raine, Keiran, Jones, David R, Teague, Jon W, Beal, Kathryn, Latimer, Calli, O'Neill, Laura, Zamora, Jorge, Anderson, Elizabeth, Patel, Nikita, Maddison, Mark, Ng, Bee Ling, Graham, Jennifer, Garnett, Mathew J, McDermott, Ultan, Nik-Zainal, Serena, Campbell, Peter J, Stratton, Michael R
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 07.03.2019
Témata:	APOBEC Deaminases - genetics APOBEC Deaminases - metabolism Cell Line Cell Line, Tumor Databases, Genetic DNA - metabolism DNA Mutational Analysis - methods Exome Genome, Human - genetics Heterografts Humans Mutagenesis Mutation - genetics Mutation Rate Neoplasms - genetics Retroelements Whole Exome Sequencing - methods APOBEC deaminases cancer cell lines episodic mutagenesis xenografts mutational signatures
ISSN:	1097-4172, 1097-4172
On-line přístup:	Zjistit podrobnosti o přístupu
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