Architectural and Functional Commonalities between Enhancers and Promoters

With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be revisited. These control elements can now be characterized in terms of their local and regional architecture, their regulatory components, incl...

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Veröffentlicht in:Cell Jg. 162; H. 5; S. 948 - 959
Hauptverfasser: Kim, Tae-Kyung, Shiekhattar, Ramin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 27.08.2015
Schlagworte:
Animals
DNA-Directed RNA Polymerases - metabolism
Enhancer Elements, Genetic
Gene Expression Regulation
Humans
Promoter Regions, Genetic
RNA, Long Noncoding - metabolism
Transcription Factors - metabolism
Transcription, Genetic
ISSN:1097-4172
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Beschreibung
Zusammenfassung:With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be revisited. These control elements can now be characterized in terms of their local and regional architecture, their regulatory components, including histone modifications and associated binding factors, and their functional contribution to transcription. This Review discusses unifying themes between promoters and enhancers in transcriptional regulatory mechanisms.
Bibliographie:ObjectType-Article-1
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ObjectType-Feature-3
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ObjectType-Review-2
ISSN:1097-4172
DOI:10.1016/j.cell.2015.08.008