Fates of CD8+ T cells in Tumor Microenvironment

Studies have reported a positive correlation between elevated CD8+ T cells in the tumor microenvironment (TME) and good prognosis in cancer. However, the mechanisms linking T cell tumor-infiltration and tumor rejection are yet to be fully understood. The cells and factors of the TME facilitate tumor...

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Published in:Computational and structural biotechnology journal Vol. 17; pp. 1 - 13
Main Authors: Maimela, Nomathamsanqa Resegofetse, Liu, Shasha, Zhang, Yi
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.01.2019
Research Network of Computational and Structural Biotechnology
Elsevier
Subjects:
biotechnology
CD8+ T cell differentiation
CD8+ T cell fates
CD8+ T cell trafficking
CD8-positive T-lymphocytes
cell growth
immunosuppression
neoplasms
prognosis
Review
T cell exhaustion
Tumor microenvironment
T cell exhaustion
CD8+ T cell differentiation
CD8+ T cell fates
Tumor microenvironment
CD8+ T cell trafficking
ISSN:2001-0370, 2001-0370
Online Access:Get full text
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Summary:Studies have reported a positive correlation between elevated CD8+ T cells in the tumor microenvironment (TME) and good prognosis in cancer. However, the mechanisms linking T cell tumor-infiltration and tumor rejection are yet to be fully understood. The cells and factors of the TME facilitate tumor development in various ways. CD8+ T cell function is influenced by a number of factors, including CD8+ T cell trafficking and localization into tumor sites; as well as CD8+ T cell growth and differentiation. This review highlights recent literature as well as currently evolving concepts regarding the fates of CD8+ T cells in the TME from three different aspects CD8+ T cell trafficking, differentiation and function. A thorough understanding of factors contributing to the fates of CD8+ T cells will allow researchers to develop new strategies and improve on already existing strategies to facilitate CD8+ T cell mediated anti-tumor function, impede T cell dysfunction and modulate the TME into a less immunosuppressive TME.
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These authors contributed equally to this work.
ISSN:2001-0370
2001-0370
DOI:10.1016/j.csbj.2018.11.004