Fates of CD8+ T cells in Tumor Microenvironment

Studies have reported a positive correlation between elevated CD8+ T cells in the tumor microenvironment (TME) and good prognosis in cancer. However, the mechanisms linking T cell tumor-infiltration and tumor rejection are yet to be fully understood. The cells and factors of the TME facilitate tumor...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Computational and structural biotechnology journal Ročník 17; s. 1 - 13
Hlavní autoři: Maimela, Nomathamsanqa Resegofetse, Liu, Shasha, Zhang, Yi
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.01.2019
Research Network of Computational and Structural Biotechnology
Elsevier
Témata:
biotechnology
CD8+ T cell differentiation
CD8+ T cell fates
CD8+ T cell trafficking
CD8-positive T-lymphocytes
cell growth
immunosuppression
neoplasms
prognosis
Review
T cell exhaustion
Tumor microenvironment
T cell exhaustion
CD8+ T cell differentiation
CD8+ T cell fates
Tumor microenvironment
CD8+ T cell trafficking
ISSN:2001-0370, 2001-0370
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Studies have reported a positive correlation between elevated CD8+ T cells in the tumor microenvironment (TME) and good prognosis in cancer. However, the mechanisms linking T cell tumor-infiltration and tumor rejection are yet to be fully understood. The cells and factors of the TME facilitate tumor development in various ways. CD8+ T cell function is influenced by a number of factors, including CD8+ T cell trafficking and localization into tumor sites; as well as CD8+ T cell growth and differentiation. This review highlights recent literature as well as currently evolving concepts regarding the fates of CD8+ T cells in the TME from three different aspects CD8+ T cell trafficking, differentiation and function. A thorough understanding of factors contributing to the fates of CD8+ T cells will allow researchers to develop new strategies and improve on already existing strategies to facilitate CD8+ T cell mediated anti-tumor function, impede T cell dysfunction and modulate the TME into a less immunosuppressive TME.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
These authors contributed equally to this work.
ISSN:2001-0370
2001-0370
DOI:10.1016/j.csbj.2018.11.004