Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1

Although many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron biology and whether they converge on common pathways to cause neuronal degeneration. Here, we have combined reprogrammi...

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Vydané v:	Cell stem cell Ročník 14; číslo 6; s. 781
Hlavní autori:	Kiskinis, Evangelos, Sandoe, Jackson, Williams, Luis A, Boulting, Gabriella L, Moccia, Rob, Wainger, Brian J, Han, Steve, Peng, Theodore, Thams, Sebastian, Mikkilineni, Shravani, Mellin, Cassidy, Merkle, Florian T, Davis-Dusenbery, Brandi N, Ziller, Michael, Oakley, Derek, Ichida, Justin, Di Costanzo, Stefania, Atwater, Nick, Maeder, Morgan L, Goodwin, Mathew J, Nemesh, James, Handsaker, Robert E, Paull, Daniel, Noggle, Scott, McCarroll, Steven A, Joung, J Keith, Woolf, Clifford J, Brown, Robert H, Eggan, Kevin
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 05.06.2014
Predmet:	Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Humans Motor Neurons - metabolism Motor Neurons - pathology Mutation Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1
ISSN:	1875-9777, 1875-9777
On-line prístup:	Zistit podrobnosti o prístupe
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