Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Associative Learning

Animals rely on the relative timing of events in their environment to form and update predictive associations, but the molecular and circuit mechanisms for this temporal sensitivity remain incompletely understood. Here, we show that olfactory associations in Drosophila can be written and reversed on...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell Jg. 178; H. 1; S. 60
Hauptverfasser: Handler, Annie, Graham, Thomas G W, Cohn, Raphael, Morantte, Ianessa, Siliciano, Andrew F, Zeng, Jianzhi, Li, Yulong, Ruta, Vanessa
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 27.06.2019
Schlagworte:
Animals
Association Learning - physiology
Behavior, Animal - physiology
Conditioning, Classical - physiology
Dopamine - metabolism
Dopaminergic Neurons - metabolism
Drosophila - physiology
Drosophila Proteins - metabolism
Mushroom Bodies - physiology
Neuronal Plasticity
Odorants
Receptors, Dopamine - metabolism
Receptors, Dopamine D1 - metabolism
Reward
Smell - physiology
Synaptic Potentials - physiology
Time Factors
associative learning
memory
Drosophila
mushroom body
G-protein second messengers
olfaction
synaptic plasticity
dopamine
ISSN:1097-4172, 1097-4172
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Animals rely on the relative timing of events in their environment to form and update predictive associations, but the molecular and circuit mechanisms for this temporal sensitivity remain incompletely understood. Here, we show that olfactory associations in Drosophila can be written and reversed on a trial-by-trial basis depending on the temporal relationship between an odor cue and dopaminergic reinforcement. Through the synchronous recording of neural activity and behavior, we show that reversals in learned odor attraction correlate with bidirectional neural plasticity in the mushroom body, the associative olfactory center of the fly. Two dopamine receptors, DopR1 and DopR2, contribute to this temporal sensitivity by coupling to distinct second messengers and directing either synaptic depression or potentiation. Our results reveal how dopamine-receptor signaling pathways can detect the order of events to instruct opposing forms of synaptic and behavioral plasticity, allowing animals to flexibly update their associations in a dynamic environment.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2019.05.040