Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Associative Learning

Animals rely on the relative timing of events in their environment to form and update predictive associations, but the molecular and circuit mechanisms for this temporal sensitivity remain incompletely understood. Here, we show that olfactory associations in Drosophila can be written and reversed on...

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Podrobná bibliografie
Vydáno v:	Cell Ročník 178; číslo 1; s. 60
Hlavní autoři:	Handler, Annie, Graham, Thomas G W, Cohn, Raphael, Morantte, Ianessa, Siliciano, Andrew F, Zeng, Jianzhi, Li, Yulong, Ruta, Vanessa
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 27.06.2019
Témata:	Animals Association Learning - physiology Behavior, Animal - physiology Conditioning, Classical - physiology Dopamine - metabolism Dopaminergic Neurons - metabolism Drosophila - physiology Drosophila Proteins - metabolism Mushroom Bodies - physiology Neuronal Plasticity Odorants Receptors, Dopamine - metabolism Receptors, Dopamine D1 - metabolism Reward Smell - physiology Synaptic Potentials - physiology Time Factors associative learning memory Drosophila mushroom body G-protein second messengers olfaction synaptic plasticity dopamine
ISSN:	1097-4172, 1097-4172
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Shrnutí:	Animals rely on the relative timing of events in their environment to form and update predictive associations, but the molecular and circuit mechanisms for this temporal sensitivity remain incompletely understood. Here, we show that olfactory associations in Drosophila can be written and reversed on a trial-by-trial basis depending on the temporal relationship between an odor cue and dopaminergic reinforcement. Through the synchronous recording of neural activity and behavior, we show that reversals in learned odor attraction correlate with bidirectional neural plasticity in the mushroom body, the associative olfactory center of the fly. Two dopamine receptors, DopR1 and DopR2, contribute to this temporal sensitivity by coupling to distinct second messengers and directing either synaptic depression or potentiation. Our results reveal how dopamine-receptor signaling pathways can detect the order of events to instruct opposing forms of synaptic and behavioral plasticity, allowing animals to flexibly update their associations in a dynamic environment.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1097-4172 1097-4172
DOI:	10.1016/j.cell.2019.05.040