Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments

Receptor endocytosis is a fundamental step in controlling the magnitude, duration, and nature of cell signaling events. Confluent endothelial cells are contact inhibited in their growth and respond poorly to the proliferative signals of vascular endothelial growth factor (VEGF). In a previous study,...

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Veröffentlicht in:	The Journal of cell biology Jg. 174; H. 4; S. 593
Hauptverfasser:	Lampugnani, Maria Grazia, Orsenigo, Fabrizio, Gagliani, Maria Cristina, Tacchetti, Carlo, Dejana, Elisabetta
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 14.08.2006
Schlagworte:	Antigens, CD - metabolism Cadherins - metabolism Cell Compartmentation - drug effects Cell Compartmentation - physiology Cell Membrane - metabolism Cell Proliferation - drug effects Cells, Cultured Endocytosis - drug effects Endocytosis - physiology Endothelial Cells - metabolism Endothelial Cells - ultrastructure Enzyme Activation - drug effects Enzyme Activation - physiology Humans Intracellular Membranes - metabolism Intracellular Membranes - ultrastructure Mitogen-Activated Protein Kinase 3 - metabolism Phospholipase C gamma - metabolism Phosphorylation Protein Phosphatase 1 Protein Tyrosine Phosphatases - metabolism Receptor-Like Protein Tyrosine Phosphatases, Class 3 Signal Transduction - drug effects Signal Transduction - physiology Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor A - pharmacology Vascular Endothelial Growth Factor Receptor-2 - agonists Vascular Endothelial Growth Factor Receptor-2 - metabolism
ISSN:	0021-9525
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