Farnesoid X receptor (FXR): Structures and ligands

[Display omitted] Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved in the metabolic process of bile acid synthesis, transport and reabsorption and is also involved in t...

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Veröffentlicht in:	Computational and structural biotechnology journal Jg. 19; S. 2148 - 2159
Hauptverfasser:	Jiang, Longying, Zhang, Huajun, Xiao, Desheng, Wei, Hudie, Chen, Yongheng
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.01.2021 Research Network of Computational and Structural Biotechnology Elsevier
Schlagworte:	Agonists Antagonists bile bile acids biotechnology domain drugs Farnesoid X receptor intestines Ligand binding domain ligands liver metabolism resorption Review Structure therapeutics Farnesoid X receptor Agonists Antagonists Structure Ligand binding domain
ISSN:	2001-0370, 2001-0370
Online-Zugang:	Volltext
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