Farnesoid X receptor (FXR): Structures and ligands

[Display omitted] Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved in the metabolic process of bile acid synthesis, transport and reabsorption and is also involved in t...

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Vydané v:	Computational and structural biotechnology journal Ročník 19; s. 2148 - 2159
Hlavní autori:	Jiang, Longying, Zhang, Huajun, Xiao, Desheng, Wei, Hudie, Chen, Yongheng
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier B.V 01.01.2021 Research Network of Computational and Structural Biotechnology Elsevier
Predmet:	Agonists Antagonists bile bile acids biotechnology domain drugs Farnesoid X receptor intestines Ligand binding domain ligands liver metabolism resorption Review Structure therapeutics Farnesoid X receptor Agonists Antagonists Structure Ligand binding domain
ISSN:	2001-0370, 2001-0370
On-line prístup:	Získať plný text
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